• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1997 Fiscal Year Final Research Report Summary

Research on simultaneous measurement of refractive index and thickness of bilogical tissue by low coherence interferometry

Research Project

Project/Area Number 08455039
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied optics/Quantum optical engineering
Research InstitutionOsaka University

Principal Investigator

HARUNA Masamitsu  Fac.Med., Dept.Allied Health Sci., Professor, 医学部, 教授 (20029333)

Co-Investigator(Kenkyū-buntansha) OHMI Masato  Fac.Med., Dept.Allied Health Sci., Research Associate, 医学部, 助手 (60273645)
ITO Kazuyoshi  Fac.Eng., Dept.Applied Phys., Professor, 工学部, 教授 (80113520)
NIDSHIHARA Hiroshi  Fac.Eng., Dept.Electron.Eng., Professor, 工学部, 教授 (00029018)
Project Period (FY) 1996 – 1997
KeywordsLow coherence interferometry / Refractive index and thickness measurement / in vitro measurement / Confocal microscopy
Research Abstract

The research has been made to demonstrated a novel low coherence interferometer which can provide simultaneous measurement of the refractive index and thickness of biological tissue. Major research results are described in the following.
1. We proposed and demonstrated a novel technique for simultaneous measurement of refractive index n and thickness t of a measured object. The technique is based on the low coherence interferometry combined with precise translation stages. It is applicable for accurate measurement of refractive index of biological tissue. The measurement accuracy of <0.1% is expected for a thickness of more than 1mm. In the experiment using the object scanning method, the accuracy of 0.2% or less was attained for nearly 1-mm thick transparent plates.
2. On the basis of our proposed method, refractive index and thickness measurement were successfully achieved for a human nail, tooth, chicken tissue and a crustacean which has multiple layrs.
3. We suggest that this method is applicable for birefringence measurement without any polarization control. The ordinary and extraordinary indices, n_o and n_e of a X-cut LiNbO_3 plate were measured.
4. Moreover, we propose and demonstrate a novel technique for simultaneous measurement of plase and group lidices n_p and n_g of a transparent plate, as well as the thickness t, using the low coherence interferometer where a single superluminescent diode is used as the light source.
5. To realize a stable and compact measurement system, the low coherence interferometer consisted of micro-optic components on a breadboard of 50 x 50cm^2.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Yusaku Shimaoka: "Nanosecond stroboscopic microscope for laser ablation of biological tissue" Conf.Laser & Electro-Optics/Pacific Rim(CLEO/PR´97). FF3. 261-262 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 春名 正光: "光CTへのアプローチ-低コヒーレンス光干渉法を中心として-" 医用画像情報学会雑誌. 11. 74-82 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masato Ohmi: "Simultaneous measurement of refractive index and thickness of transparent plates by low coherence interferometry" Optical Review. 4. 507-515 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 春名 正光: "光干渉による生体内部構造の検出" 日本ME学会雑誌BME. 11. 34-40 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 春名 正光: "生体光計測の現状と将来" 光学. 26. 457-460 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masamitsu Haruna: "Simultaneous measurement of phase and group indices of transparent plates using the low coherence interferometry" Proc.Int´l Conf.Optical Fiber Sensors(OFS´97). OThC23. 496-499 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 満山 照樹: "低コヒーレンス光干渉による屈折率と厚さ同時精密測定-位相・群屈折率の導入-" 応用物理学会 光波センシング技術研究会. LST20-12. 41-48 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 丸山 英樹: "低コヒーレンス光干渉による屈折率と厚さ同時測定-屈折率波長分散を考慮した精密測定と樹脂硬化度の評価-" 電子情報通信学会 光エレクトロニクス研究会. OPE97-539. 25-30 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 春名 正光(共著): "飯沼武他編「医用物理学」第6章 医用光学" 医歯薬出版株式会社, 45 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yusaku Shimaoka: "Nanosecond stroboscopic microscope for laser ablation of biological tissue" Conf.Laser & Electro-Optics /Pacific Rim (CLEO/PR'97). FF3. 261-262 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masamitsu Haruna: "An approach to Optical CT-Low coherence interferometry-" Medical Imaging and Information Sciences. Vol.14. 74-82 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masato Ohmi: "Simultaneous measurement of refractive index and thickness of transparent plates by low coherence interferometry" Optical Review. Vol.4. 507-515 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masamitsu Haruna: "Detection/imaging of inner structure of biological tissue by optical interferometry" Bio Medical Engineering. Vol.11. 34-40 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masamitsu Haruna: "Future and recent progress of biomedical optics" Japanese Journal of Optics. Vol.26. 456-460 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masamitsu Haruna: "Simultaneous measurement of phase and group indices of transparent plates using the low coherence interferometry" Tech.Dig.11th Int'l Conf.Optical Fiber Sensors (OFS'97). OThC23. 496-499 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1999-03-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi