1998 Fiscal Year Final Research Report Summary

Pathogenesisi of anemia induced by babesia in domestic animals

Research Project

Project/Area Number	08456156
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Applied veterinary science
Research Institution	HOKKAIDO UNIVERSITY
Principal Investigator	MAEDE Yoshimitsu Grad.Sch.of Vet.Med., Hokkaido Univ., Prof., 大学院・獣医学研究科, 教授 (40002084)
Co-Investigator(Kenkyū-buntansha)	YAMATO Osamu Grad.Sch.of Vet.Med., Hokkaido Univ., Inst., 大学院・獣医学研究科, 助手 (80261337) TAJIMA Motoshi Grad.Sch.of Vet.Med., Hokkaido Univ., Lec., 大学院・獣医学研究科, 講師 (90202168)
Project Period (FY)	1996 – 1998
Keywords	Babesia / Anemia / Oxidative damage / Erythrocytes / Spleen / Platelet
Research Abstract	The pathogenesis of anemia in dogs with babesiosis was studied. The results were as follows. 1. Oxidative damage to erythrocytes was induced by the multiplication of Babesia gibsoni. 2. Ultrastructural study have revealed that red pulp of infected dogs contained many platelets in the splenic cords and sinuses. As a result, it appeared to be difficult for many erythrocytes to pass from cords to sinuses. These results suggest that the cause of anemia in dogs with babesiosis was mainly due to the sequestration of erythrocytes in the spleen, in which the destruction of erythrocytes with oxidative damage might be accelerated.

(2 results)