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1996 Fiscal Year Final Research Report Summary

Endothelial Modulation of Vascular Remodeling

Research Project

Project/Area Number 08457062
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionKyushu University

Principal Investigator

SUEISHI Katsuo  Kyushu University, Faculty of Medicine, Professor, 医学部, 教授 (70108710)

Co-Investigator(Kenkyū-buntansha) TASHIRO Yoshihiko  Kyushu University, Faculty of Medicine, Assistant, 医学部, 助手 (10188237)
HASHIMOTO Shuichi  Kyushu University, Faculty of Medicine, Assistant, 医学部, 助手 (00243931)
KONO Shinji  Kyushu University, School of Health Science, Assistant Professor, 医療技術短期大学部, 助教授 (20225379)
NAKAGAWA Kazunori  Kyushu University, Faculty of Medicine, Assistant, 医学部, 助手 (50217668)
NAKASHIMA Yutaka  Kyushu University, Faculty of Medicine, Assistant, Professor, 医学部, 助教授 (50135349)
Project Period (FY) 1996
Keywordsgene therapy / HVJ-lipsome method / VEGF / p53 / atherosclerosis / angiogenesis / apoptosis / NO
Research Abstract

1. Vascular remodeling and intimal neovascularization : 1) The density of intimal angiogenesis in human corrnary arteries was well correlated to the atherosclerotic luminal stenosis, and its activity represented one of histological characteristics of atherosclerotic progression, 2) VEGF expressed by smooth muscle cells and macrophages participated in this angiogenic process. 3) VEGF gene transfer by the HVJ-liposome method induced angiomatoid proliferation in fibrocellularly thickened intima of rabbit carotid arteries.
2. Biological characteristics of gene transfer method with HVJ-liposomes : The transfer efficiency and cytotoxic effects of this method was estimated in vascular wall, hepatic sinusoids, respiratory system and cancer cells.
3. Wild-type p53 gene transfer was highly effective to suppress the intimal thickening following balloon injury.
4. Chronic suppression of vascular NO synthesis with L-NAME induced myocardial arteriosclerosis probably via the activation of renin-angiotensis system within vascular wall.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Toshinori Murata: "The temporal and spatial vascular endothelial growth factor expression in retinal vasculogenesis of rat neonates." Lab Invest. 74. 68-77 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshikazu Yonemitsu: "In situ detection of frequent and active infection of human cytomegalovirus in inflammatory abdominal aortic aneurysms." Lab Invest. 74. 723-736 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toshinori Murata: "The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas." Lab Invest. 74. 819-825 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toshiaki Kadokami: "Altered serotonin receptor subtypes mediate caronary microvascular hyperreactivity in pigs with chronic inhibition of nitric oxide synthesis." Circulation. 94. 182-189 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshikazu Yonemitsu: "Characterization of in vivo gene transfer into the arterial wall mediated by the Sendai virus (hemagglutinating virus of Japan) liposomes." Lab Invest. 75. 313-323 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yusri Ali Elsayed: "Effects of recombinant human tissue factor pathway inhibitor on thrombus formation and its in vivo distribution in a rat DIC model." Am J Clin Pathol. 106. 574-583 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 居石克夫: "血栓症治療" メディカルレビュー社, 16 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石橋達朗: "血管新生のメカニズムと疾患" 医薬ジャーナル社, 11 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toshinori Murata: "The temporal and spatial vascular endothelial growth factor expression in retinal vasculogenesis of rat neonates." Lab Invest. 74. 68-77 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshikazu Yonemitsu: "In situ detection of frequent and active infection of human cytomegalovirus in inflammatory abdominal aortic aneurysms." Lab Invest. 74. 723-736 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toshinori Murata: "The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas." Lab Invest. 74. 819-825 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toshiaki Kadokami: "Altered serotonin receptor subtypes mediate coronary microvascular hyperreactivity in pigs with chronic inhibition of nitric oxide synthesis." Circulation. 94. 182-189 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshikazu Yonemitsu: "Characterization of in vivo gene transfer into the arterial wall mediated by the Sendai virus (hemagglutinating virus of Japan) liposomes." Lab Invest. 75. 313-323 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yusri Ali Elsayd: "Effects of recombinant human tissue factor pathway inhibitor on thrombus formation and its in vivo distribution in a rat DIC model." Am J Clin Pathol. 106. 574-583 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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