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1996 Fiscal Year Final Research Report Summary

Study on abnormality in growth regulation hepatic carcinogenesis and its control.

Research Project

Project/Area Number 08457166
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionOsaka University

Principal Investigator

KAWATA Sumio  Osaka University, Medical School, Associate Professor, 医学部, 助教授 (90183285)

Co-Investigator(Kenkyū-buntansha) KISO Shinichi  Osaka University, Hospital, Fellow, 医学部・附属病院, 医員
MATSUDA Yukihiko  Osaka University, Medical School, Assistant, 医学部, 助手 (90283770)
TAMURA Shinji  Osaka University, Medical School, Assistant, 医学部, 助手 (30243223)
Project Period (FY) 1996
Keywordshepatocellular cacinoma / TGF-beta receptor / cell growth / 細胞増殖
Research Abstract

We have studied molecular mechanisms of human hepatocarcinogenesis from the view of the point that hepatocytes have an autonomous proliferative potential due to a loss of the responsiveness to a potent negative growth regulator, TGF-beta. Previously, we found poor response of human hepatoma-derived cell lines to TGF-beta.
Hepatocellular carcinoma (HCC) occurs in the liver with HBV-or HCV-related cirrhosis. We introduced HBx gene into mink lung epithelial cell, a cell line which is very sensitive to TGF-beta. The responsiveness to TGF-beta in the transfectants was much poorer than that in the parent cells. In addition, the reduced responsiveness seemed to result from a decrease in expression of TGF-beta receptors. The hepatocytes could escape from the negative growth regulation by TGF-beta due to expression of HBx gene during chronic HBV infection.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] O. Oshikawa, S. Tamura S. Kawata, et al.: "The effect of hepatitis B virus gene expression on response to growth inhibition by TGF-β1" Biochem. Biophys. Res. Cpmmun.222 (3). 770-773 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H, Tsushima, S. Kawata, et al.: "High levels of TGF-β1 in patients with colorectal cancer : Association with disease progretion" Gastroenterology. 110 (2). 375-382 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N. Ito, S. Kawata, et al.: "Induction of interleukin-6 by interferon-α and its abrogation by a serine protease inhibitor in patients with chronic hepatitis C." Hepatology. 23 (4). 669-675 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N. Ito, S. Kawata, et al.: "Increased circulating TGF-β1 in a patient with giant hepatic hemangioma ; Possible contribution to impaied immune tunction." Hepatology. 25 (1). 93-96 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T. Nagase, S. Kawata, et al.: "Inhibition of cell growth of hepatoma cell line (HepG^2) by a farnesyl : protein transferase inhibitor." Int. J. Cancer. 65. 620-626 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N. Ito, S. Higashiyama, S. Kawata, et al.: "Regulation of heparin-binding growth factor expression by phorbal ester in a human hepatoma-derived cell line" Biochem. Biophys. Acta. 1310. 163-167 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田村信司,河田純男: "細胞増殖因子療法" メディカル レビュー社, 333 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 河田純男: "消化器病セミナー62" へるす出版, 228 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] O.Oshikawa, S.Kawata, et al.: "The effect of hepatitis B virus gene expression on response to growth inhibition by TGF-beta1" Biochem.Biophys.Res.Commun.222(3). 770-773 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Tsushima, S.Kawata, et al.: "HIGH LEVELS OF TGF-beta 1 in patients with colorectal cncer : Association with disease progression" Gastroenteology. 110(2). 375-382 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Ito, S.Kawata, et al.: "Induction of interleukin-6 by interferon-alfa and its abrogation by a serine protease inhibitor" Hepatology. 23(4). 669-675 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Ito, S.Kawata, et al.: "Increased circulating TGF-beta 1 in a patient with giant hepatic hemangioma : Possible contribution to impaired immune function" Hepatology. 25(1). 93-96 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Nagase, S.Kawata, et al.: "Inhibition of cell growth of hepatoma cell line (Hep G2) by a farnesyl : proteintransferase inhibitor" Int.J.Cancer. 65. 620-626 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Ito, S.Higashiyama, S.Kawata, et al.: "Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line" Biochim.Biophys.Acta. 1310. 163-167 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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