1996 Fiscal Year Annual Research Report

肺癌の放射線治療による局所制御に関連する因子の免疫組織化学的・臨床的検討

Research Project

Project/Area Number	08457237
Research Category	Grant-in-Aid for Scientific Research (B)
Research Institution	Gunma University
Principal Investigator	新部英男群馬大学, 医学部, 教授 (90008293)
Co-Investigator(Kenkyū-buntansha)	長谷川正俊群馬大学, 医学部, 助手 (50251111) 斉藤吉弘群馬大学, 医学部, 助手 (50170543) 早川和重群馬大学, 医学部, 講師 (70114189)
Keywords	肺癌 / 非小細胞肺癌 / アポトーシス / 放射線治療 / 放射線感受性 / がん関連遺伝子 / 免疫組織化学 / タキソ-ル
Research Abstract	1.放射線誘導アポトーシスと関連する遺伝子(産物)の免疫組織化学的検索ヌードマウスを用いた実験結果からは,照射後6時間で採取した組織中に出現するアポトーシスの頻度が高い腫瘍の放射線感受性は高く,頻度の低い腫瘍の放射線感受性が低いことは明らかになってきた.しかし,検索した範囲内での癌関連遺伝子の発現とアポトーシスならびに放射線感受性とには明らかな関連性を認めることはできていない.今後の期待としては,p53の発現とアポトーシスとの関係で,p53に依存するアポトーシスが存在する腫瘍もあるので,放射線治療開始まえのp53の検索が先行指標となりうる可能性が示唆された. 2.アポトーシスを誘発するとされている開発中の化学薬剤Taxolとの併用効果の検討 Taxolと放射線との併用効果をin vitroの系で2種類の腫瘍を用いて検索した範囲では,アポトーシスの頻度が増加しても,放射線感受性は相加効果の域を超えていなかった.今後は,腫瘍による差異をヌードマウス可移植腫瘍を用いて検討する. 3.病理組織型別の局所制御率とアポトーシスとの関係を明らかにし放射線感受性の再評価扁平上皮癌については,p53の発現と予後について検討し,p53陰性腫瘍の予後がやや良好であることを示唆するデーターをえた.さらにアポトーシスとの関係へと発展させたい. 4.局所制御に要する線量を腫瘍径・組織型別に検討し至適線量を求める. 放射線治療を行った肺癌症例につき検討し,扁平上皮癌については,肉眼的腫瘍の存在しない縦隔の予防照射では,40Gyでほぼ制御できることがわかった.

Research Products

(11 results)

All Other

All Publications (11 results)

[Publications] Hayakawa,K.: "Definitive radiation therapy for medically inoperable patients with stage I and II non-small cell lung cancer" Radiation Oncology Investigations. 4. 165-170 (1996)
[Publications] Hayakawa,K.: "High-dose radiation therapy for inoperable non-small cell lung cancer without mediastinal involvement (Clinical stage N0. N1)" Strahlenther Oncol. 172. 489-495 (1996)
[Publications] Nakamoto,S.: "An interaction of cisplatin and radiation in two rat yalk sac tumour cell lines with different radiosensitivities in vitro" Int J Radiat Biol. 70(6). 747-753 (1996)
[Publications] Mitsuhashi,N.: "A radioresistant variant cell line,NMT-1R,isolated from a radiosensitive rat yolksac tumour cell line,NMT-1 : differences of early radiation-induced morphological changes,especially apotosis" Int J Radiat Biol. 69(3). 329-336 (1996)
[Publications] Milas,L.: "Therapeutic potential of paclitaxel-radiation treatment of a murine ovarian carcinoma" Radiotherapy & Oncology. 40. 163-170 (1996)
[Publications] Ebara,T.: "Prognostic significance of immunohistochemically detected p53 protein expression in stage IIIB squamous cell carcinoma of the uterine cervix treated with radiation thisapy alone" Gynecologic Oncology. 63. 216-218 (1996)
[Publications] Sakurai,H.: "Enhanced cytotoxicity in combination of low dose-rate irradiation with hyperthermia in vitro" Int J Hyperthermia. 12(3). 355-366 (1996)
[Publications] Hayakawa,K.: "The role of radiotherapy for stageIIIB non-small cell lung cancer : Impact of clinical nodal stage on survival" Int J Clin Oncol. 1(1). 13-17 (1996)
[Publications] Furuta,M.: "Radiation therapy for stage I-II non-small cell lung cancer in patients aged 75 years and older" Jpn J Clin Oncol. 26. 95-98 (1996)
[Publications] Hayakawa,K.: "Impact of cumor extent and location on treatment outsome in patients with Stage III non-small cell lung cancer treated with radiation therapy" Jpn J Clin Oncol. 26. 221-228 (1996)
[Publications] Saito,Y.: "Prognostic lactors for invasive thymoma treated with radiation therapy Hone or combination of surgery and radiation therapy" The Kitakanto Medical Journal. 47(1). 19-23 (1997)

1996 Fiscal Year Annual Research Report

肺癌の放射線治療による局所制御に関連する因子の免疫組織化学的・臨床的検討

Principal Investigator

新部 英男 群馬大学, 医学部, 教授 (90008293)

Research Products

[Publications] Hayakawa,K.: "Definitive radiation therapy for medically inoperable patients with stage I and II non-small cell lung cancer" Radiation Oncology Investigations. 4. 165-170 (1996)

[Publications] Hayakawa,K.: "High-dose radiation therapy for inoperable non-small cell lung cancer without mediastinal involvement (Clinical stage N0. N1)" Strahlenther Oncol. 172. 489-495 (1996)

[Publications] Nakamoto,S.: "An interaction of cisplatin and radiation in two rat yalk sac tumour cell lines with different radiosensitivities in vitro" Int J Radiat Biol. 70(6). 747-753 (1996)

[Publications] Mitsuhashi,N.: "A radioresistant variant cell line,NMT-1R,isolated from a radiosensitive rat yolksac tumour cell line,NMT-1 : differences of early radiation-induced morphological changes,especially apotosis" Int J Radiat Biol. 69(3). 329-336 (1996)

[Publications] Milas,L.: "Therapeutic potential of paclitaxel-radiation treatment of a murine ovarian carcinoma" Radiotherapy & Oncology. 40. 163-170 (1996)

[Publications] Ebara,T.: "Prognostic significance of immunohistochemically detected p53 protein expression in stage IIIB squamous cell carcinoma of the uterine cervix treated with radiation thisapy alone" Gynecologic Oncology. 63. 216-218 (1996)

[Publications] Sakurai,H.: "Enhanced cytotoxicity in combination of low dose-rate irradiation with hyperthermia in vitro" Int J Hyperthermia. 12(3). 355-366 (1996)

[Publications] Hayakawa,K.: "The role of radiotherapy for stageIIIB non-small cell lung cancer : Impact of clinical nodal stage on survival" Int J Clin Oncol. 1(1). 13-17 (1996)

[Publications] Furuta,M.: "Radiation therapy for stage I-II non-small cell lung cancer in patients aged 75 years and older" Jpn J Clin Oncol. 26. 95-98 (1996)

[Publications] Hayakawa,K.: "Impact of cumor extent and location on treatment outsome in patients with Stage III non-small cell lung cancer treated with radiation therapy" Jpn J Clin Oncol. 26. 221-228 (1996)

[Publications] Saito,Y.: "Prognostic lactors for invasive thymoma treated with radiation therapy Hone or combination of surgery and radiation therapy" The Kitakanto Medical Journal. 47(1). 19-23 (1997)

新部英男群馬大学, 医学部, 教授 (90008293)