1997 Fiscal Year Final Research Report Summary
A role for macrophage scavenger receptors in altherosclerosis and susceptibility to infection
| Project/Area Number |
08457258
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
内分泌・代謝学
|
|---|
| Research Institution | Research Center for Advanced Science and Technology University of Tokyo |
|---|
Principal Investigator |
KODAMA Tatsuhiko University Tokyo, , Research Center for Advanced and Technology, Chair Professor, 先端科学技術研究センター, 教授 (90170266)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WADA Youithirou Japan Foundation for Aging and Health, Research Resident, リサーチレジデント
NAKAZIMA Atsushi University of Tokyo, , The Third Department of Internal Medicine, Assistant Prof, 医学部・第三内科, 助手
ABURATANI Hiroyuki University of Tokyo, , The Third Department of Internal Medicine, Assistant Prof, 医学部・第三内科, 助手 (10202657)
|
|---|
| Project Period (FY) |
1996 – 1997
|
| Keywords | macrophage / scavenger receptor / knockout mice / foam cell / atherosclerosis / スフェロプラストフュージョン |
|---|
| Research Abstract |
Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated uptake of modified low-density lipoprotains (mLDL). MSR-A can bind an extraordinarily wide range of ligands, including bacterial pathogens, and also mediates cation-independent macrophage adhesion in vitro. Herer we show that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E.Macrophages from MSR-A-deficient mice show a marked decrease in mLDL uptake in vitro, whereas mLDL clearance from plasma occurs at a normal rate, indicating that there may be alternative mechanisms for removing mLDL from the circulation.In addition, MSR-A-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type-1, indicating that MSR-A may play a part in host defense against pathogens.
|
Research Products
(12 results)
