1998 Fiscal Year Final Research Report Summary
cytokines, elastase and pulmonary surfactant in tracheal aspirates from in fants who developed chron lungdisease.
| Project/Area Number |
08457291
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
CHIDA Shoichi Iwate Medical University Department of Pediatrics, Professor, 医学部, 教授 (30108930)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Akio Iwate Medical University the medical department Instractor, 医学部, 講師 (70163235)
SHIMADA Senji Iwate Medical University the medical department assistant profess, 医学部, 助教授 (30091804)
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| Project Period (FY) |
1996 – 1998
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| Keywords | chronic lung disease / cytokines / elastase / pulmonary surfactant |
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| Research Abstract |
To determine if release of inflammatory mediators into the airways or abnormality of pulmonary surfactant is associated with later development of chronic lung disease (CLD), we measured concentrations of interleukin-6 (IL-6), IL-8, tumor necrosis factor a (TNF- alpha), granulocyte elastase, surfactant proteins (SF-A and SP-B,C), and stable tnicrobubble count in tracheal aspirates from 121 infants weighing less than 1500 g who required mechanical ventilation.
The concentrations of IL-8 and elastase in infants who subsequently developed CLD (n=23) were significantly higher than those in infants without CLD (n = 98) at 1, 3, 4 and 5 days of age. CLD group had significantly higher level of TNF- alpha at 21 days of age. Multiple logistic regression analysis revealed that factors affecting the development of CLD during the first 5 days of age were increased levels of IL-8 and elastase in tracheal aspirates, and the severity of lung disease.
These results indicate that IL-8, elastase and TNF-alpha play important roles in the development of CLD.
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Research Products
(2 results)
