1998 Fiscal Year Final Research Report Summary
Study of functional resection of cirtical epileptogenic foci by cortical cooling
| Project/Area Number |
08457357
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Tokyo |
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Principal Investigator |
SUZUKI Ichiro University of Tokyo Hospital, Department of Neurosurgery, Lecturee, 医学部・附属病院, 講師 (30162928)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Kensuke University of Tokyo Hospital, Department of Neurosurgery, Assistant, 医学部・附属病院, 助手 (70260924)
SUGISHITA Morihiro Tokyo University, Department of Cognitive Neuroscience, Professor, 医学部, 教授 (10114513)
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| Project Period (FY) |
1996 – 1998
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| Keywords | Epilepsy / Cerebral cortex / Cerebral cooling / Radiation |
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| Research Abstract |
It is necessary to determine the spacial extent of epileptogenic foci and the functional role of epileptogenic zone in the epilepsy surgery for the cortical epilepsy. It is not difficult to define the central area of the epileptogenic zone, but is difficult to demarcate the marginal zone of the epileptogenic zone. It is also difficult to differentiate between the epileptic activity and the activity electrotonically conducted from the remote epileptogenic zone. From this point of view, it is ideal to interfere transiently the cortical activity in order to evaluate the epileptogenic zone and cortical function. Based on these clinical and sientific background, we evaluated the new technique of the cortical cooling for transient and reversible inactivation of epileptogenic foci. In order to analyze the usefulness of this method, we made animal models such as NER (Noda epileptic rat) and EL mouse. However, the volume of the brain of rats or mice was to small to cool the regional brain or whole brain. Furthermore ; stable cooling of the brain of these animals was also difficult. We therefore analysed the effect of the radiation on the epileptogenic activity in these animals. The inhibitory effect of the radiation on the epileptic activity was revealed. We also studied the effect of the regional cooling on the cerebral epileptic activity in man.
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