1997 Fiscal Year Final Research Report Summary
Study of pathogenesis of adrenal-regeneration hypertension with special reference to vascular protein synthesis
| Project/Area Number |
08457420
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Yamagata University |
|---|
Principal Investigator |
NAKADA Teruhiro Yamagata University, School of Medicine, Professor, 医学部, 教授 (50009495)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISHIGOOKA Manabu Yamagata University, School of Medicine, Assistant Professor, 医学部, 助手 (20202989)
SASAGAWA Isoji Yamagata University, School of Medicine, Assistant Professor, 医学部, 講師 (80196146)
KUBOTA Yoko Yamagata University, School of Medicine, Associate Professor, 医学部, 助教授 (60125763)
|
|---|
| Project Period (FY) |
1996 – 1997
|
| Keywords | adrenal / hypertension / collagen / elastin |
|---|
| Research Abstract |
1) Increased incorporation of ^3H-proline into the collagen in the heart was remarkable in the chronic phase of adrenal-regeneration hypertensive (ARH) rats. Administration of alpha 1 blocker effectively suppressed such protein synthesis concomitant with reduction of blood pressure. Incorporation of ^3H-proline into the cardiac elastin remained unchanged. Similar results were also obtained in the mesenteric arteries in hypertensive ARH rats. Unilateral nephrectomy and bilateral adrenal enucleation in salt-loaded rats evoked hypertension (ARH). Treatment with desoxycorticosterone (DOCA) too ARH rats further enhanced incorporation into the collagen and non-collagenous protein in such DOCA-treated ARH rats with rapid development of remarkable hypertension. Administration of beta blocker failed to reduce such vascular protein synthesis and hypertension vascular collagen and non-collagenous protein play and important role for the pathogenesis hypertension.
2) Collagen, non-collagenous protein and elastin were determinde in renal and testicular arteries in humons. High amount of non-collagenous protein was noted in the testicular arteries in hypertensive patients. Linear postine relationship was seen between blood pressure and the content of non-collatenous protein. These results indicate that increased synthesis of testicular arteries appears to raise the blood pressure in human beings.
3) Our follow-up study of patients with primary aldosteronism showed that tumor-uninbolved adrenal cortex regenerated in 11monthes. Such study was done by visualization of the partiaally resected gland by CT or scintigraphy in addition to endocrine analysis.
|
