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1998 Fiscal Year Final Research Report Summary

Mechanism of iontransports in the cells of the auditory system.

Research Project

Project/Area Number 08457453
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionMiyazaki Medical College (1997-1998)
Kyushu University (1996)

Principal Investigator

KOMUNE Shizuo  Miyazaki Medical College, Dept.of Otolaryngol., Chairman, 医学部, 教授 (10117434)

Project Period (FY) 1996 – 1998
KeywordsEndocochlear potential / Na-K-Cl contransport / endolymph / Cochlea
Research Abstract

Ouabain(1mM) applied in the perilymphatic space of the guinea-cochlea decreased the endolymphatic potential(EP) to the maximum negative level of approximately 30 mV and also did the potassium activity of endolymph([K]e). After EP reached the maximum negative potential , the perilymphatic space was perfused with Cl-free, Na-free, or 2 mM of furosemide containing 1mM of ouabait in each solution. Cl-free and Na-free inhibited the decrease of [K]e due to 1 mM of ouabain. 2mM of furosemide also inhibited the decrease of [K]e. EP did not changed during these experiments. These findings is an evidence that there exists a Na-K-Cl cotransporter in the in vivo cocblea, which is directed toward from perilymph to endolymph, ouabain-insennsitive and neutral electrically.

  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] Kimitsuki, T., Hisashi, K., Komune, S., Komiyama, S.: "Elavation of intracellular cacium ion modifies mechano-electrical transduction current in chick cochlear hair cells." Proc.Sendai Ear Symposium. 6. 141-144 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 君付 隆、平 俊明、辻 剛二 小宗静男、小宮山荘太郎: "生理的条件下での蝸牛有毛細胞トランスデューサー電流・ナイスタチン穿孔法による記録" 頭頸部自律神経. 11. 15-17 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimitsuki, T., Nakagawa, T., Hisashi, K. Tsuji, K., Komune, S., Komiyama, S.: "Elevation of intracellular calcium induced by the intrapipette perfusion technique modifies membrane ion currents in the chick cochlear hair cell." Acta Otolaryngol(Stockh). 118. 70-73 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimitsuki, T., Hisashi, K., Komune, S., Komiyama, S.: "Elavation of intracellular cacium ion modifies mechano-electrical transduction current in chick cochlear hair cells." Proc.Sendai Ear Symposium. 6. 141-144 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimitsuki, T., Nakagawa, T., Hisashi, K., Tsuji, K., Komune, S., komiyama, S.: "Elevation of intracellular calcium induced by the intrapipette perfusion technique modifies membrane ion currents in the chick cochlear hair cell." Acta Otolaryngol (Stockh). 118. 70-73 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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