1996 Fiscal Year Final Research Report Summary
STUDY FOR INTRACELLULAR SIGNAL TRANSDUCTION MECHANISM OF TGF-beta SUPERFAMILY.
| Project/Area Number |
08457495
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
ICHIJO Hidenori Japanese Foundation for Cancer Research The Cancer Institute, Dept.Biochemistry, Principal Investigator, 癌研究所生化学部, 主任研究員 (00242206)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Kohsuke Japanese Foundation for Cancer Research The Cancer Institute, Dept.Biochemistry,, 癌研究所生化学部, 研究員
MIYAZONO Kohei Japanese Foundation for Cancer Research The Cancer Institute, Dept.Biochemistry,, 癌研究所生化学部, 部長 (90209908)
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| Project Period (FY) |
1996
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| Keywords | TGF-beta / TGF-beta superfamily / GDF / BMP / Receptor serine / threonine kinase |
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| Research Abstract |
The members in the TGF-beta superfamily appear to have essential roles in development and cancer. The relationship between the TGF-beta superfamily ligands and their receptors is not well understood in the context of their specificity and affinity. In order to analyze the ligand-receptor relationship as well as signal transduction mechanism, we performed following studies. 1) The receptors for GDF-5 was identified by affinity cross-linking using iodinated GDF-5.2) The signals for growth inhibition and matrix induction by TGF-beta was found to be separated by introducing mutations into TGF-beta type I receptor. 3) A new gene termed BMP/OP-responsive gene (BORG) was isolated by a differential dis, play method. 4) A novel MAPKKK,ASKI was isolated and found to be a key component of the signal transduction of apoptosis.
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[Publications] Saitoh, M., Nishitoh, H., Amagasa, T., Miyazono, K., Takagi, M.and Ichijo, H.: "Identification of important regions in the cytoplasmic domain of type I receptor that separate signaling pathways of transforming growth factor-beta." J.Biol.Chem.271. 2769-2775 (1996)
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「研究成果報告書概要(欧文)」より
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[Publications] Nishitoh, H., Ichijo, H., Kimura, M., Matsumoto, T., Makishima, F., Yamaguchi, A., Yamashita, H., Enomoto, S.and Miyazono, K.: "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5." J.Biol.Chem.271. 21345-21352 (1996)
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「研究成果報告書概要(欧文)」より
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[Publications] Harumiya, S., Takeda, K., Sugiura, T., Fukumoto, Y., Tachikawa, H., Miyazono, K., Fujimoto, D.and Ichijo, H.: "Charactrization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1." J.Biochem.120. 745-751 (1996)
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「研究成果報告書概要(欧文)」より
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[Publications] Okadome, T., Oeda, E., Saitoh, M., Ichijo, H., Moses, H.L.Miyazono, K.and Kawabata, M.: "Characterization of the interaction of FKBP12 with the transforming growth factopr-beta type I receptor in vivo." J.Biol.Chem.271. 21687-21690 (1996)
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「研究成果報告書概要(欧文)」より
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[Publications] Ichijo, H., Nishida, E., Irie, K., ten Dijke, P., Saitoh, M., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K.and Gotoh.: "Y.Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways" Science. 275. 90-94 (1997)
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「研究成果報告書概要(欧文)」より
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[Publications] Olofsson, A., Hellman, U., ten Dijke, P., Grimsby, S., Ichijo, H., Moren, A.Miyazono, K.and Heldin, C-H.: "A latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160." Biochemical Journal. 324. 427-434 (1997)
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「研究成果報告書概要(欧文)」より
