Immuno-Gene Therapy for the Oral Squamous Cell Carcinoma using with Anti-Tumor Cytotoxic T-Lymphocytes.

1998 Fiscal Year Final Research Report Summary

• Project/Area Number: 08457541
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TAKAHASHI Yuzo tokyo Medical and Dental University, Faculty of Detistry, The 2nd Department of Oral and Maxillofacial Surgery, Associate Professor., 歯学部, 助教授 (50014329)
• Project Period (FY): 1996 – 1998
• Keywords: Immuno-Gene Therapy / MHC-restricted anti-tumor cytotoxic T-lymhocytes / Oral squamous cell carcinoma / CD80-modified human tumor cells / 特異的免疫療法

Research Abstract

Many trials for the generation of MHC-restricted anti-tumor cytotoxic T lymhocytes against squamous cell carcinoma of head and neck region including oral cavity, have been studied. However, it is usually difficult toachieve.
One of the reasons of this difficulty, is the lack of CD8O molecules on the surface of tumor cells. We induced the CD8O molecules into the tumor cells using adeno-vilus vectors. Efficient generation of anti-tumor cytotoxic T lymphocytes are generated with CD8O-modified human tumor cells and IL-12. However, the sufficient number of effector cells for the patients therapy can not be generated.