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1998 Fiscal Year Final Research Report Summary

Clinico-virological study for latent multiple infections by herpes simplex virus type 1

Research Project

Project/Area Number 08457561
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKurume University

Principal Investigator

KAMEYAMA Tadamistu  Medical department, Kurume University, Professor, 医学部, 教授 (00080937)

Co-Investigator(Kenkyū-buntansha) HUJITA Hiroshi  Medical department, Kurume University, Assistant, 医学部, 助手 (10248453)
TERASAKI Sinitirou  Medical department, Kurume University, Assistant, 医学部, 助手 (70227510)
Project Period (FY) 1996 – 1998
Keywordsherpes simplex virus type 1 / latent multiple infection / shedding virus / DNA cleavage / growth curve / released virus / infective virus
Research Abstract

To confirm the occurrence of latent multiple infections by herpes simplex virus type 1 (HSV-1), we studied the clinico-virologic findings. The results obtained were as follows :
1) The viral clone isolated from 12 viral strains shed into saliva of malignant patients and 10 viral strains obtained from the herpetic focus were analyzed using DNA cleavage patterns.
In asymptomatically shed viral strains, only 1 of 12 strains (8.7%) had different clones, suggesting the existence of simultaneous reactivation in multiple latent HSV-1 infections.
2) The degree of released virus after 17 hours of inoculation and the characters of the growth curve during 24 hours of inoculation were compared with asymptomatic viruses and infectious viruses. The degree of released virus in the asymptomatic group was lower than that of the infectious group.
Moreover, different patterns in the growth curve were seen between the two groups. The pattern in the asymptomatic group showed a peak 18 hours after inoculation and decreased suddenly, while that of the infectious group showed a peak 15 hours after inoculation and decreased slowly.
3) DNA cleavage patterns of inoculative and reactive viruses on experimental corneal HSV-1 inoculation in mice were analyzed.
HSV-1 used in these experiments consisted of an asymptomatic virus shed into saliva and an infectious virus isolated from herpetic lesions.
In the inoculation of the virus strain alone, DNA cleavage patterns were identical.
However, in the inoculation of mixed shed and infectious viruses, and different viruses in both eyes respectively, all reactive viruses had DNA patterns of the infectious virus. This finding suggests the presence of a preference strain in reactivation following HSV-1 latent multiple infections.

  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] 江頭朋子, 他: "三叉神経帯状疱疹患者唾液への単純ヘルペスウイルスの排出" 日本口腔科学会雑誌. 45・1. 86-90 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 寺崎伸一郎, 他: "口腔領域における単純ヘルペスウイルス1型感染症の検討" 日本口腔科学会雑誌. 45・3. 323-325 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤政孝志: "単純ヘルペスウイルス1型に起因する口腔粘膜再発病変の臨床的ウイルス学的検討" 臨床とウイルス. 24・1. 69-77 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 関 直子, 他: "飛沫汚染に関する臨床ウイルス学的検討" 歯界展望. 別冊. 261-261 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐藤敬一郎: "単純ヘルペスウイルス1型の再活性化とNK細胞活性" 久留米医学会雑誌. 60・1. 19-27 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林吉史: "顎顔面領域における単純ヘルペスウイルス1型初感染症例の臨床的ウイルス学的検討" 日本口腔科学会雑誌. 46・2. 137-146 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 寺崎伸一郎, 他: "口腔領域におけるヘルペス感染症での細胞診の検討-Thin Prepを利用した細胞収集法について-" 日本口腔粘膜学会雑誌. 3・1. 33-36 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小嶺 徹, 他: "単純ヘルペスウイルス1型初感染後の再発病態を観察した2症例" 日本口腔科学会雑誌. 47・3. 392-396 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T Kameyama, et al: "A case of recurrent herpetic infection of the oral floor -A case report-" Kurume Med.J.43. 78-80 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S Terasaki: "Latent dual infections by herpes simplex virus type 1" Kurume Med.J.43. 127-136 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y Kobayashi, et al: "Two Cases of Recurrent Herpetic Infection of the Tongue" Kurume Med.J.43. 237-241 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S Terasaki, et al: "A case of zoster in the 2nd and 3rd branches of the trigeminal nerve associated with simultaneous herpes labialis infection -A case report-" Kurume Med.J.44. 61-66 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M Nakao: "Analyses of herpes simplex virus clones isolated from the focus and aaliva" Kurume Med.J.44. 289-296 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T Kobayashi, et al: "Brush cytology of herpes simplex virus infection in oral mucosa : use of the ThinPrep Processor" Diagnostic Cytopathology. 18. 71-75 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y Nagao, et al: "Hepatitis C virus RNA detection in oral lichen planus tissue" AM.J.Gastroenterol.93. 850-850 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 分担執筆 亀山忠光: "有病者・高齢者歯科治療マニュアル" 医歯薬出版, 284 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 分担執筆 亀山忠光: "歯科口腔外科テキスト" 医学情報社, 230 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tomoko Egashira, et al: "Excretion of herpes simplex virus type1 into saliva in patient with zoster of trigeminal nerve" J.Jpn.Stomatol.Soc.45. 86-90 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shinitirou Terasaki, et al: "Evaluation of cytodiagnosis for herpes simplex virus type-1 infections in the oral cavity" Jpn.J.Oral Maxillo.Surg.42. 323-325 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Fujimasa, et al: "Clinical and virological studies of herpeticrecrrent infections on the oral macosa" Clinical Virology. 24. 67-77 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tadamitsu Kameyama, et al: "A case of recurrent herpetic infection of the oral floor-A case report-" The Kurume Medical Journal. 43. 78-80 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shinichiro Terasaki, et al: "Latent dual infections by herpes simplex virus type 1" The Kurume Medical Journal. 43. 127-136 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshihumi Kobayashi, et al: "Two Cases of Recurrent Herpetic Infection of the Tongue" The Kurume Medical Journal. 43. 237-241 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tadao Kobayashi, et al: "Brush cytology of oral herpes simplex virus infection using immunocytochemistry ; use of the thinprep processor" 10th International congress of Histochemistry and cytochemistry. 1-2 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Keiichiro Sato: "Immunological study on reactivation of latency infectesd herpes simplex virus type-1 in relation to natural killer-cell activity" J.Kurume Med.Associat.60. 19-27 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshifumi Kobayashi: "Clinical and virological study on primary infection of herpes simplex virus type-1 in maxillofacial region" J.Jpn.Stomatol.Soc.46. 137-146 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shinitiro Terasaki, et al: "Evaluation of cytodiagnosis for herpes virus infection in oral cavity" J.Jpn.Oral Muco.Membr.3. 33-36 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shinitirou Terasaki, et al: "A case of zoster in the 2nd and 3rd branches of the trigeminal nerve associated with simultaneous herpes labialis infection -A case report-" The Kurume Medical Journal. 44. 61-66 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mototsugu Nakao: "Analyses of herpes simplex virus clones isolated from the focus and aaliva" The Kurume Medical Journal. 44. 289-296 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tooru Komine, et al: "Recurrent behavior after primary infection with herpes simplex virus type 1 -Report of 2 cases-" J.Jpn.Stomatol.Soc.47. 392-396 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tadao Kobayashi, et al: "Brush cytology of herpes simplex virus infection in oral mucosa ; use of the ThinPrep Processor" Diagnostic Cytopathology. 18. 71-75 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yumiko Nagao, et al: "Hepatitis C virus RNA detection in oral lichen planus tissue" Am.J.Gastroenterol. 93. 850 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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