1997 Fiscal Year Final Research Report Summary
Development and Application of the Conceptionally New Catalytic Asymmetric Aldol Reaction
| Project/Area Number |
08457580
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIBASAKI Masakatsu The University of Tokyo The Graduate School of Pharmaceutical Sciences, Professor, 大学院薬学系研究科, 教授 (30112767)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Takayoshi The University of Tokyo The Graduate School of Pharmaceutical Sciences, Research, 大学院薬学系研究科, 助手 (80272483)
SASAI Hiroaki The University of Tokyo The Graduate School of Pharmaceutical Sciences, Associat, 大学院薬学系研究科, 助教授 (90205831)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Aldol / Asymmetric Catalyst / Palladium / エノールシリルエーテル |
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| Research Abstract |
Developing a catalytic asymmetric aldol reaction is a formidal challenge nowadays. Chiral Lewis acid catalysts have been reported. However, this approach still has many problems in versatility and applicability. Thus, we investigated novel approach by using the chiral palladium catalyst. We have found that the aldol reaction proceeds in high yield and ee via the palladium enolate even in the presence of small amount of water. Furthermore, we have investigated and determined the catalyst structure and the reaction mechanism.
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