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1997 Fiscal Year Final Research Report Summary

Evaluation of the metabolisms of calcium and magnesium in the cardiovascular diseases

Research Project

Project/Area Number 08457639
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

OSHIMA Tetsuya  Hiroshima University School of Medicine, Associate Professor, 医学部, 助教授 (40233100)

Co-Investigator(Kenkyū-buntansha) MATSUURA Hideo  Hiroshima University Medical Hostpital, Assistant Professor, 医学部・附属病院, 講師 (50136040)
KAMBE Masayuki  Hiroshima University of School of Medicine, Professor, 医学部, 教授 (70034139)
Project Period (FY) 1996 – 1997
KeywordsCalcium / Magnesium / Hypertension / Angina Pectoris / Arrythmia / Diabetes Mellitus / Platelets / Erythrocytes
Research Abstract

1. Although the deficiency of Ca or Mg has been suggeested to be associated with the cardiovascular diseases, the appropriate evaluation of the metabolism of these cations is not established. In the present study, we determined whether there is an abnormality in the systemic or cellular metabolism of Ca orMg in several cardiovascular diseases.
2. In patients with arrythmia, serum ionized Mg^<2+> concentration was reduced, whereas serum concentrations of total Ca and total Mg, and erythrocyte Mg concentration were normal.
3. In patients with coronary artery diseases, such as myocardial infarction, effort angina and vasospastic angina, serum concentrations of Ca^<2+> and Mg^<2+>, and erythrocyte Mg concentration were normal.
4. In patients with essential hypyertension, while serum concentrations of Ca^<2+> and Mg^<2+> were normal, [Mg^<2+>] i in platelets and erythrocytes, and Mg retention were increased.
5. In patients with diabetes mellitus, serum ionized Mg^<2+> concentration was decreased, while serum concentrations of Ca^<2+> and total Mg and erythrocyte Mg were normal.
6. All the indices were normal in patients with hyperlipidemia.
7. Although serum concentration of total Ca and total Mg were normal in the cardiovascular diseases, serum ionized Mg^<2+> was reduced in diabetes mellitus and arrythmia, and intracellular Mg concentration was increased in essential hypertension.

  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Hiroyuki Hiraga: "Angiotensin I-converting enzyme gene polymorphism and salt sensitivity in essential hypertension" Hypertension. 27. 569-572 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yukihito Higashi: "Renal response to 1-arginine in salt sensitive patients with essential hypertension" Hypertension. 27. 643-648 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Norihisa Ono: "Platelet Ca^<2+> is not increased in stroke prone spontaneously hypertensive rats" Hypertension. 27. 1312-1317 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mari Ishida: "Effects of insulin on calcium metabolism and platelet aggregation" Hypertension. 28. 209-212 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitsuisa Yoshimura: "Potentiotion of the intracellular Ca^<2+> response to arginine vasopressin by increased cytosolic free Mg^<2+>" Biochemica et Biophysica Acta. 1312. 151-157 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ryoji Ozono: "Modulation of traget tissue response to angiotensin II and sodium sensitivity in Japanese patients with essential hypertension" Hypertension Research. 19. 141-145 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitsuisa Yoshimura: "Extracellular Mg^<2+> inhibits capacitive Ca^<2+> entry in vascular smooth muscle cells" Circulation. 95. 2567-2572 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yukihito Higashi: "Relationship between insulin resistance and endothelium-dependent vascular relaxation in patients with essential hypertension" Hypertension. 29. 280-285 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yukihito Higashi: "Nocturnal decline in blood pressure is attenuated by NaCl loading in salt-sensitive patients with essential hypertension" Hypertension. 30. 163-167 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yukihito Higashi: "Aging and severity of hypertension attenuate endothlium-dependent renal vascular relaxation in humans" Hypertension. 30. 252-258 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitsuisa Yoshimura: "Differential effects of extracellular Mg^<2+> on thrombin-induced and capacitative Ca^<2+> entry in human coronary arterial endothelial cells" Arteriosclerosis,Thrombosis,and Vascular Biology. 17. 3356-3361 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ryoji Ozono: "Change in blood pressure during altered sodium intake in not associated with calciotropic hormone level" Clinical Science. 93. 153-157 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yukiko Nakano: "Angiotensin I-converting enzyme gene polymorphism and acutu response to captopril in essential hypertension" American Journal of Hypertension. 10. 1064-1068 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nobuo Sasaki: "Lack of effect of transmenmbrane gradient of magnesium and sodium on regulation of cytosolic free magnesium concentration in rat lymphocytes" Biochimica et Biophysica Acta. 1329. 493-498 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroyuki Hiraga: "Angiotensin I-converting enzyme gene polymorphism and salt sensitivity in essential hypertension" Hypertension. 27. 569-572 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yukihito Higashi: "Renal response to l-arginine in salt sensitive patients with essential hypertension" Hypertension. 27. 643-648 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Norihisa Ono: "Platelet Ca^<2+> is not increased in stroke prone spontaneously hypertensive rats" Hypertension. 27. 1312-1317 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mari Ishida: "Effects of insulin on calcium metabolism and platelet aggregation" Hypertension. 28. 209-212 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitsuisa Yoshimura: "Potentiotion of the intracellular Ca^<2+> response to arginine vasopressin by increased cytosolic free Mg^<2+>" Biochemica et Biophysica Acta. 1312. 151-157 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ryoji Ozono: "Modulation of target tissue response to angiotensin II and sodium sensitivity in Japanese patients with essential hypertension" Hypertension Research. 19. 141-45 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitsuisa Yoshimura: "Extracellular Mg^<2+> inhibits capactive Ca^+ entry in vascular smooth muscle cells" Circulation. 95. 2567-2572 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yukihito Higashi: "Relationship between insulin resistance and endothelium-dependent vascular relaxation in patients with essential hypertension" Hypertension. 29. 280-285 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yukihito Higashi: "Nocturnal decline in blood pressure is attenuated by NaCl loading in salt-sensitive patients with essential hypertension" Hypertension. 30. 163-167 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yukihito Higashi: "Aging and severity of hypertension attenuate endothelium-dependent renal vascular relaxation in humans" Hypertenion. 30. 252-258 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitsuisa Yoshimura: "Differential effects of extracellular Mg^<2+> entry in human coronary arterial endothelial cells" Arteriosclerosis, Thrombosis, and Vascular Biology. 17. 3356-3361 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ryoji Ozono: "Change in blood pressure during altered sodium intake in not associated with calciotropic hormone level" Clinical Science. 93. 153-157 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yukiko Nakano: "Angiotensin I-converting enzyme gene polymorphism and acute response to captopril in ssential hypertension" American Journal of Hypertension. 10. 1064-1068 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nobuo Sasaki: "Lack of effect of transmenmbrane gradient of magnesium and sodium on regulation of cytosolic free magnesium concentration in rat lymphocytes" Biochimica et Biophysica Acta. 1329. 493-198 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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