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1998 Fiscal Year Final Research Report Summary

USEFULNES OF LABORATORY HAIRLESS DOG IN THE DEVELOPMENT OF DERMAL MEDICINES AND COSMETICS

Research Project

Project/Area Number 08556049
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Applied veterinary science
Research InstitutionThe University of Tokyo

Principal Investigator

DOI Kunio  The University of Tokyo, Graduate School of Agricultural and Life Sciences, Professor, 大学院・農学生命科学研究科, 教授 (70155612)

Co-Investigator(Kenkyū-buntansha) KIMURA Tohru  Nihon Nosan Kogyo Co.Ltd, Research Center, Sinior Researcher, 中央研究所, 主任研究員
ITAGAKI Shin-ichi  The University of Tokyo, Graduate School of Agricultural and life sciences, Asso, 大学院・農学生命科学研究科, 助教授 (00159823)
NAKAYAMA Hiroyuki  The University of Tokyo, Graduate School of Agricultural and Life Sciences, Asso, 大学院・農学生命科学研究科, 助教授 (40155891)
Project Period (FY) 1996 – 1998
KeywordsLaboratory hailess dog / Sunscreens / Screening system / Hair growth stimulator / Anti-acne agent / Depigmenthing agent / Depressant of skin aging
Research Abstract

Usefulness of laboratory hairless dog (LHD) which have been developed by us in the development of dermal medicines and cosmetics were investigated from the various viewpoints. The results of this study are summarized as follows.
1) The epidermis of LHD contained abundant melanocytes. Their skin clearly showed UV-induced changes such as senburn and suntan reactions.
2) Sunscreens effectively protected the skin of LHD from sunburn and suntan reactions induced by solar exposure or artificial UV-irradiation.
3) Neonatal LHD developed hair growth reactions following minoxidil treatment.
4) The spotted pigmentation occurring on the skin of adult LHD was depigmented by application of HQ.
5) LHD developed spontaneous comedons in the skin and the severity of these lesions subsided with the application of anti-acne agents.
6) Aging of the skin of LHD was delayed by all-trans-retinoic acid treatment.
These results strongly suggest that LHD is very useful laboratory animal in the development of dermal medicines and cosmetics.

  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Kimura T: "Studies on development of hairless descendants of Mexican hairless dogs and their usefulness in dermatelogical science." Exp.Anim.45. 1-13 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura T.and Doi K.: "Spontaneous comedones on the skin of hairless descendants of Mexican hairless dogs." Exp.Anim.45. 377-384 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura T.and Doi K.: "The effect of topical minoxidil treatment on hair follicular growth of neonatal hairless descendants of Mexican hairless dogs." Vet.Dermatol.8. 107-113 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura T.and Doi K.: "Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs." Hisotol Histopathol.13. 29-36 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura T.and Doi K.: "Efficacy of hydroguinone in the tre treatment of cutaneous hyperpigmentation in hairless descendants of Mexican hairless dogs." Lob.Anim.Sci.48. 469-475 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura T.and Doi K.: "Effects of all-trans-retinoic acid on the dorsal skin of hairless dogs." Toxicol.Pathol.26. 595-601 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura T.: "Ohshima S.and Doi K.Haematological and serum biochemicl values in hairless and haired descendants of Mexican hairless dogs." Lab.Anim.26. 214-218 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura T.: "Ohshima S.and Doi K.The inheritance and breeding results of hairless descendants of Mexican hairless dogs." Lab.Anim.27. 55-58 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura T.and Doi K.: "Responses of the skin over the dorsum to sunlight in hairless descendants of Mexiacn hairless dogs." Am.J.Vet.Sci.55. 199-203 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura T.and Doi K.: "Age-related changes in skin color and histologic features of hairless descendants of Mexican hairless dogs." Am.J.Vet.Sci.55. 480-486 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura T.and Doi K.: "Protective effects of sunscreens on sunburn and suntan reactions in cross-bred Mexican hairless dogs." Vet.Dermatol.5. 175-187 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura T.and Doi K.: "dorsal skin reactions to sunlight and artificial ultraviolet light in hairless descendants of Mexicam hairless dogs." Exp.Anim.44. 293-299 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishii Y., Kimura T., Itagaki S.and Doi K.: "Ultrastructure of the dorsal skins of hairless descendants derived from Mexicam hairless dogs." Exp.Anim.44. 353-357 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura T.: "Studies on development of hairless descendants of Mexican hairless dogs and their usefulness in dermatological science." Exp.Anim.45. 1-13 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura T.and Doi K.: "Spontaneous comedones on the skin of hairless descrendants of Mexican hairless dogs." Exp.Anim.45. 377-384 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura T.and Doi K.: "The effect of topical minoxidil treatment on hair follicular growth of neonatal hairless descendants of Mexican hairless dogs." Vet.Dermatol.8. 107-113 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura T.and Doi K.: "Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs." Hist.Histopathol.13. 29-36 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura T.and Doi K.: "Efficacy of hydroquinone in the treatment of cutaneous hyperpigmentation in descendants of Mexican hairless dogs." Lab.Anim.Sci.48. 469-475 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura T.and Doi K.: "Effects of all-trans-retinoic acid on the dorsal skin of hairless dogs." Toxicol.Pathol.26. 595-601 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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