| Project/Area Number |
08558082
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Neuroscience in general
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| Research Institution | Tohoku University |
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Principal Investigator |
ITOH Masatoshi Tohoku University Cyclotron RI Center, Division of Nuclear Medicine, Professor, サイクロトロンRIセンター, 教授 (00125501)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Takehiko Cyclotron RI Center, Div.of Nuclear Medicine, Research Chief, サイクロトロンRIセンター, 助手 (70238632)
NAKAMURA Takashi Cyclotron RI Center, Div.of Radioprotection, Professor, サイクロトロンRIセンター, 教授 (70026029)
MIYAZAWA Tatsuo Japan IBM inc, Tokyo Basic Research Institute, Senior Researcher, 副主任研究員
TAKAHASHI Akiyoshi Tohoku University School of Medicine, Department of Radiology, Associate Prof., 医学部, 教授 (80148874)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Brain Activation / MRI / Brain Function / Positron Tomography / Blood Flow / Brain Imaging |
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| Research Abstract |
The aim of this study is to establish a functional brain mapping approach using 3-D positron camera (PET) and functional magnetic resonance imaging (fMRI). A rapid 3D-image reconstruction (1 min per a block data of 63 slices) was achieved using parallel processing algorithm and Tohoku University Super Computer (SX4, NEC inc, Japan), (Ann Nucl Med, 1997). 3D-dynamic data acquisition after injection of ^<15>O labeled water enabled absolute cerebral blood flow calculation without arterial blood sampling (J Cereb Blood Flow Metabol, 1996). Radiation exposure to subjects could reduced to 1/10^<th> of usual 2D data sampling (J Nucl Med, 1997). Anatomical brain standardization software was developed using affine linear image transformation to a template PET image set. Accuracy of this system and the SPM96 was tested by comparing 20 Japanese and 20 British brain images and found that transformation was successful if non-linear transformation was applied. Several clinical researches were carried out using this system for PET and fMRI (Neurosurg Psychiat, 1997 ; J Intl Soc Life Info Sci, 1997 ; Am J Neuroradiol, 1997)
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