| Project/Area Number |
08558090
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
YAMAMOTO Katsuyuki Graduate School of Engineering, Hokkaido University, Pro., 大学院・工学研究科, 教授 (10088867)
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| Co-Investigator(Kenkyū-buntansha) |
SHIGA Toshikazu Omron Institute of Life Science Co., Ltd., Researcher, 研究員
KUDO Nobuki Graduate School of Engineering, Hokkaido University, Inst., 大学院・工学研究科, 助手 (30271638)
TAKAHASHI Makoto Graduate School of Engineering, Hokkaido University, Asso.Pro., 大学院・工学研究科, 助教授 (10154858)
SHIMIZU Koichi Graduate School of Engineering, Hokkaido University, Pro., 大学院・工学研究科, 教授 (30125322)
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| Project Period (FY) |
1996 – 1998
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| Keywords | near-infrared light / tissue oximeter / muscle tissue / fat layer / Monte Carlo simulation / optical properties of tissue |
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| Research Abstract |
A portable tissue oximeter based on two-wavelength near-infrared spectroscopy with multiple photo sensors was developed for a real-time, ambulatory measurement of muscle oxygenation. This oximeter can eliminate the influences of inhomogeneous structure of tissues on the measurement and is useful for quantitative evaluation of muscle oxygenation in the fields of sports and rehabilitation medicine as well as in muscle tissue physiology. Important results of this study are summarized as follows.
Development of the portable tissue oximeter : The oximeter was made compact for the ambulatory measurement using LED as a light source. Photo sensors were placed at distances of 20, 30 and 40 mm from the light source for the oxygenation measurement of the muscle with various thicknesses of fat layers. An algorithm for obtaining oxygenation was determined by systematic analyses of reflectance, based on the light diffusion theory and tissue phantom experiments.
Correction of the influences of a subcut
… More
aneous fat layer and the skin : Influence of a subcutaneous fat layer was systematically examined through Monte Carlo simulation, phantom experiments and in vivo measurements. A correction method for decrease in measurement sensitivity due to the presence of a fat layer was established. Effects of the skin and skin blood flow were also studied, and it was found that these effects can be eliminated using an additional near-by photo sensor 3 mm distant from the light source.
Evaluation of the system in practical applications : To evaluate the usefulness of the developed system, oxygen transport capacity in the muscle tissue was measured in eleven Olympic athletes of the Nordic combined. Measured transport capacities were clearly higher than those of untrained subjects.
In vivo measurement of tissue optical properties : As basic data for determining a mean optical pathlength and for obtaining an absolute oxgenation value, optical properties of muscle tissues were successfully determined at the forearm, without the influence of a fat layer, using time-resolved spectroscopy. Less
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