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1997 Fiscal Year Final Research Report Summary

Development to Intravascular Oxygenator Designed by a Novel Gas Permeantion Ultrathin Membrane with Blood Compatibility

Research Project

Project/Area Number 08558099
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Biomedical engineering/Biological material science
Research InstitutionTOKYO METROPOLITAN UNIVERSITY

Principal Investigator

NAGAOKA Shoji  TOKYO METROPOLITAN UNIVERSITY Graduate School of Engineering, Professor, 工学研究科, 教授 (30254147)

Co-Investigator(Kenkyū-buntansha) KANAMORI Toshiyuki  National Institute of Materials and Chemical Research, Researcher, 物質工学研究所・高分子材料プロセス, 主任研究官
NAKAYAMA Youichi  TORAY Research Center Co.Ltd., Researcher, 表面科学研究部, 主任研究員
KUBOTA Sunao  St.Marianna University School of Medicine, Professor, 第一外科, 教授 (20075500)
KAWAKAMI Hiroyoshi  TOKYO METROPOLITAN UNIVERSITY Graduate School of Engineering, Associate Professo, 工学研究科, 助教授 (10221897)
Project Period (FY) 1996 – 1997
KeywordsArtificial Organ / Artificial Lung / Fluorinated Polymide / Hollow Fiber / Phase Inversion / Gas Transfer / Biocompatibility
Research Abstract

A novel asymmetric hollow fiber of fluorinated polyimide has been fabricated for intravascular oxygenator (IVOX) device. A dry /wet phase in-version process has been aplied to a spinning process to prepare an asymmetric polyimide hollow fiber. The outer surface of the hollow fiber consisted of an ultrathin skin layr. O2 and CO2 transfer rates of the polyimide hollow fiber were much larger than those determined in presently avalable polydimethylsiloxane (PDMS) hollow fiber and the transfer rates were similar to those measured in silicone-layr-coated polypropylene were similar to those measured in silicone-layr-coated polypropylene (Si-PP) hollow fiber.
The hemocompatibility of the polyimide hollow fiber without heparinization has been evaluated in vitro and in vivo. The amount of platelets on the polyimide hollow-fiber surface measured in vitro was less than that on PDMS hollow fiber and Si-PP hollow fiber. The formation of thrombus estimated in vivo was not found. This means that the asymmetric polyimide hollow fiber shows excellent biocompatibility.

  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] H.Kawakami, S.Nagaoka: "Formation of Surface Skin Layer of Asymmetric Polyimide membranes and Their Gas Transport Properties" J.Membr.Sci. 137. 241-250 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Kawakami, S.Nagaoka: "Gas Transfer and Blood Compatibility of Fluorinated Polyimide Membranes" J.Biomater.Sci.,Polym.Ed.,. 7. 1029-1038 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Kawakami, S.Nagaoka: "Synthesis of Polymeric Manganase Porphyrins and Their Targeting Ability to O^-_2・" Porphyrin. 5. 243-249 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Kawakami, S.Nagaoka: "Construction of the Ordered Surface Immobilized Bioactive with Mesogenic Group" J.Jpn.Soc.Biomater.15. 113-120 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Kawakami, S.Nagaoka: "Development of a Novel Polyimide Hollow Fiber for an Intravascular Oxygenator" ASAIO J.43. 490-494 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Kawakami, S.Nagaoka: "Behavior of Plasma Protein Adsorption of Novel Florinated Polyimide Membrane" Jap.J.Artif.Organs. 27. 250-253 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroyoshi Kawakami, Masato Mikawa, and Shoji Nagaoka: "Gas Permeabiliry and Selectivity Through Asymmetric Polyimide Membranes" J.Appl.Polym.Sci.,. Vol.62(7). 965-971 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroyoshi Kawakami, Shoji Nagaoka and Sunao Kubota: "Gas Transfer and In Vitro and In Vivo Blood Compatibility of Fluorinated Polyimide Membranes with Ultrathin Skin Layer" ASAIO J.,. Vol.42(5). M871-M876 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasumasa Mori, Hiroyoshi Kawakami, Shoji Nagaoka, Sunao Kubota, and Toshiyuki Kanamori: "Fabrication of Hollow Fiber Membrane of 6FDA Polyimide and Design of Novel Membrane Oxygenator" Jpn.J.Artif.Organs. Vol.27. 278-282 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroyoshi Kawakami, Masato Mikawa, Jun Takagi, and Shoji Nagaoka: "Gas Transfer and Blood Comatibility of Fluorinated Polyimide Membranes" J.Biomater.Sci., Polym.Ed.Vol.7(12). 1029-1038 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroyoshi Kawakami, Shoji Nagaoka and Sunao Kubota: "Gas Transfer and in Vitro and Invivo Blood Compatibility of Fluorinated Polyimide Membranes with Ultrathin Skin Layr" ASAIO J.Vol.42(5). M871-M876 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroyoshi Kawakami, Masato Mikawa, and Shoji Nagaoka: "Gas Permeability and Selectivity Through Asymmetric Polyimide Membranes" J.Appl.Polym.Sci.Vol.62(7). 965-971 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitsuyasu Kawano, Hiroyoshi Kawakami, Toshiyuki Ohse, and Shoji Nagaoka: "Syntheses of Polymeric Manganese Porphyrins and Their Evaluation of Targeting Ability to O2" Porphyrin. Vol.5(3). 243-249 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirokazu Abe, Hiroyoshi Kawakami, and Shoji Nagaoka: "Construction of the Ordered Surface Immobilized Bioactive with Mesogenic Group" J.Jpn.Soc.Biomater. Vol.15(3). 113-120 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroyoshi Kawakami, Yasumasa Mori, Jun Takagi, Shoji Nagaoka, Toshiyuki Kanamori, Toshio Shinbo, and Sunao Kubota: "Development of a Novel Polyimide Hollow Fiber for an Intravascular Oxygenator" ASAIO J.Vol.43(5). M490-M494 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroyoshi Kawakami, Masato Mikawa, and Shoji Nagaoka: "Formation of Surface Skin Layr of Asymmetric Polymide membranes and Their Gas Transport Properties" J.Membr.Sci.Vol.137. 241-250 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Keisuke Shinguu, Hiroyoshi Kawakami, and Shoji Nagaoka: "Behavior of Plasma Protein Adsorption of Novel Florinated Polyimide Membrane" Jpn.J.Artif.Organs. Vol.27. 250-253 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasumasa Mori, Hiroyoshi Kawakami, Shoji Nagaoka, Sunao Kubota, and Toshiyuki Kanamori: "Fabrication of Hollow Fiber Membrane of 6FDA Polyimide and Desing of Novel Membrane Oxygenateor" Jpn.J.Artif.Organs. Vol.27. 278-282 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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