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1997 Fiscal Year Final Research Report Summary

Control of Reactivies of Mononuclear Iron Complexes by Design of Their Ligands

Research Project

Project/Area Number 08640716
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Inorganic chemistry
Research InstitutionKumamoto University

Principal Investigator

GOTO Masafumi  Kumamoto University Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (50080180)

Co-Investigator(Kenkyū-buntansha) KUROSAKI Hiromasa  Kumamoto University Faculty of Pharmaceutical Sciences, Assistant Professor, 薬学部, 助手 (70234599)
MORI Hiromasa  Kumamoto University Faculty of Pharmaceutical Sciences, Associste Professor, 薬学部, 助教授 (40040315)
Project Period (FY) 1996 – 1997
Keywordsiron complex / dehydrogenation / polyamine / bleomycin / nitrile / C-C bond fomation / hydroperoxide / DNA
Research Abstract

Three projects were carried out according to the plan.
1.Control of Dehydrogenation Reactions of Ligands by the structure of Ligands and their Coordination Mode : The tricyano (triamine) ferrates (II) and (III) with them were prepared and their structures were charcterized. Especially, the coordination mode of di (pyridylmethyl) amine to iron, mer-and fac-coordination mode, strongly influenced on the reactivity : the former underwent smooth dehydrogenation but the latter resisted.
2.The Strucure and Reactivity of Bleomycin Model Complexes : Polymethylated bleomycin model ligands were synthesized to improve the stability of the metal binding site of the anti cancer drug of bleomycin against oxidation destruction.Fe(II), Fe(III), Cu(II), Zn(II) complexes with new ligands were prepared. As the number of methyl substitution is increased, the overall structures of Cu(II) and Zn(II) tend to change from square-pyramid to trigonal bipyramid. But the methylation rendered less capability in oxidative cleavage of DNA.
3.Bridging Reaction of Nitrles between Iron(II) and the Central Carbon of 1,3-Diimine Group Incorporatrd to the Tetradentate Ligands of the iron : One ligand was designed to fullfill the requirement and was prepared by an iron-mediated template reaction from 2,4-pentanedione and 2-aminomethylpyridine. Nitrile solution of this complex yielded new series of iron complexes with pentadentate ligands fomed via C-C bond formation between nitriles and the carbon atoms of the tetradentate ligands. This reaction is also applicable to a wide range of nitriles. The iron complexes with pentadentate ligands yielded hydroperoxide species on addition of hydrogen peroxide and are capable to cleave DNA oxidatively.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Masafumi.Goto: "Synthesis of an iron(II)complex versatile for preparation of iron(II)complexes with novel pentadentate ligands via C-C bond formation with various nitriles:1,3-dimethyl-1,3-propanediylidenebis(2-pyridylmethanamine)iron(II)perchlorate" Chem.Commun.539-540 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masafumi.Goto: "Inhibition of the metallo-β-lactamase produced from Serratia marcescens by thiol compounds" Biol.Pharm.Bull.20(11). 1136-1140 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshinobu Ishikawa: "Oxidative and random cleavage of DNA by the novel iron(II)complex capable of yielding an iron(III)hydroperoxide intermediate" Chem.Lett.39-40 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masafumi.Goto: "Iron(II)complexes with novel pentadentate ligands via C-C bond formation between various nitriles and [2,4-bis(2-pyridylmethylimino)pentane]iron(II)perchlorate:synthesis and structures" J.Chem.Soc.,Dalton Trans.in press. (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masafumi.Goto et al.: "Synthesis of an iron (II) complex versatile for preparation of iron (II) complexes with novel pentadentate ligands via C-C bond formation with various nitriles : 1,3-dimethy-1,3-propanediylidenebis (2-pyridylmethanamine) iron (II) perchlorate" Chem.Commun.539-540 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masafumi.Goto et al.: "Inhibition of the metallo-beta-lactamase produced from Serratia marcescens by thiol compoiunds." Biol.Pharm.Bull.20(11). 1136-1140 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshinobu Ishikawa et al.: "Oxidative and random cleavage of DNA by the novel iron (II) complex capable of yielding an iron (II) hydroperoxide intermediate." Chem.Lett.39-40 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masafumi. Goto et al: "Iron (II) complexes with novel pentadentate ligands via C-C bond formation between various nitriles and [2,4-bis (2-pyridylmethylimino) pentane] iron (II) perchlorate : synthesis and structures" J.Chem.Soc., Dalton Trans.(in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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