1997 Fiscal Year Final Research Report Summary

Synthesis and elucidation of new sulfated block copolysaccharides and oligosaccharides having specific anti-HIV activity

Research Project

Project/Area Number	08651041
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	高分子合成
Research Institution	HOKKAIDO UNIVERSITY
Principal Investigator	YOSHIDA Takashi Hokkaido Univ., Graduate School of Science, Associate Professer, 大学院・理学研究科, 助教授 (40166955)
Project Period (FY)	1996 – 1997
Keywords	Curdlan / Curdlan sulfate / Water insoluble / Graft copolymerization / Cross-linking / Anti-HIV activity
Research Abstract	Curdlan sulfate was found to have potent anti-HIV activity and low cytotoxicity. For the synthesis of water-insoluble curdlan sulfate which has selective affinity of HIV absorption in the infected blood, graft copolymerization of MMA onto curdlan and sulfation of the obtained copolymers were carried out.On graft copolymerization initiated by cerium ammonium nitrate, graft copolymers having various grafting percentages were obtained. The resulting graft copolymers were sulfated with piperidine-N-sulfonic acid. When the graft copolymer having grafting percentage of 88% was sulfated with 2.5eq.of piperidine-N-sulfonic acid to give the corresponding sulfated graft copolymer having S content of 3.1%. The testing of selective removal of HIV from blood will be investigated.