1997 Fiscal Year Final Research Report Summary
Molecular Design of New Polymers Having Pendant Acidic Saccharide Moieties and Its Drug Release
| Project/Area Number |
08651059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
高分子合成
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| Research Institution | Kogakuin University |
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Principal Investigator |
HASHIMOTO Kazuhiko Kogakuin Univ., Faculty of Eng., Professor, 工学部, 教授 (20023484)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Glycopolymer / D-Glucuronic Acid / Pharmacological Activity / Uronic Acid / Stirene / Radical Polymerization / Methacrylamide / Drug Delivery System |
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| Research Abstract |
Naturally occurring polymers and their composites have been noted again as useful biodegradable or biomedical materials. Various kinds of multicomponent materials have been prepared from polysaccharides and their repeating units, monosaccharides. Since D-glucuronic acid exists widely as a component of polysaccharides in animals and plants and its lactone was commercially available, it was used as a starting material for synthesis of novel amphiphilic polymers having D-glucuronyl pendants. At first, two kinds of new monomers, styryl and methacryloyl groups as a polymerizable functional group respectively, were prepared in the present work. The radical polymerization of styryl-type and methacryloyl-type monomers and their copolymerization with stirene in water or dimethyl sulfoxide proceeded in a homogeneous phase at 60ﾟC and gave colorless powdery polymer in high yield. Through the deprotection in a mixture of trifluoroacetic acid with water (2/1, v/v), the glucofuranuronyl moiety in the resulting polymers was converted to that having a pyranose ring. Solubility of deprotected polymers was found to be different from that of protected polymers in various solvents. Another new stryl-type monomer having p-nitrophenyl group at the anomeric position as a drug model was also prepared from D-glucurono-6,3-lactone. Its radical copolymerization with acrylamide gave a copolymer, which was useful for the release tests.
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Research Products
(12 results)
