1997 Fiscal Year Final Research Report Summary
Pathological significance of apoptosis in arteriosclerosis.
| Project/Area Number |
08670209
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nagoya City University |
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Principal Investigator |
TADA Toyohiro Nagoya City University, Medical School Associate Professor, 医学部, 助教授 (20106230)
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| Co-Investigator(Kenkyū-buntansha) |
KUNIMATSU Mitoshi Nagoya City University, Medical School Assistant Professor, 医学部, 講師 (70145746)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Atherosclerosis / Apoptosis / Artery / Cell death / Smooth muscle cell / Macrophage |
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| Research Abstract |
Arteriosclerotic lesions show decrease in cells including smooth muscle cells and macrophages. The ame of this project is to investigate the cause and mechanism of the decrease in the cells mentioned above.
Tissue fragments obtained by atherectomy were staied with the method of so-called TUNEL to detect the cell death, that is, apoptosis. Many cells in the atherosclerotic intima showed positive stain. These apoptotic cells were composed predominantly of smooth muscle cells, and partly of macrophages.
Immunohistochemical studies were also done. Many of the smooth muscle cells in the intima of the coronary artery were positively stained with anti-Fas antigen antibody. These results suggest that the apoptosis in the atherosclerotic arteries might be induced by the mechanism of apoptosis causeed by Fas ligand which might be expressed on the T-cells in the atherosclerotic lesion.
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[Publications] Tateyama, H., Tada, T., Hattori, H., Murase, T., Li, W-X., Eimoto, T.: "Effects of prefixation and fixation times on apoptosis detection by in situ end-labeling of fragmented DNA." Arh.Pathol.Lab.Med.122. 252-255 (1998)
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「研究成果報告書概要(欧文)」より
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[Publications] Kasugai, K., Takashi, J., Kataoka, H., Sasaki.M., Tada, T., Asai, K., Kato, T., Itoh, M.: "Evidence for participation of gliostatin/platelet-derived endothelial cell growth factor in gastric ulcer healing." Life Science. 61. 1899-1906 (1997)
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[Publications] Tateyama, H., Eimoto, T., Tada, T., Inagaki, H., Hattori, H., Takino, H.: "Apoptosis, bcl-2 prtotein, and fas antigen in thymic epithelial tumors." Mod.Pathol.10. 983-991 (1997)
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「研究成果報告書概要(欧文)」より
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[Publications] Sano, H., Tada, T., Moriyama, A., Ogawa, H., Asai, K., Kawai, Y., Hodgson, M.E., Kato, T., Wada, Y., Suchi, M.: "Isolation of a rat histidase cDNA sequence and expression in Escherichia coli.Evidence of extrahepatic/epidermal distribution." Eur.J.Biochem.250. 212-221 (1997)
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「研究成果報告書概要(欧文)」より
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