1997 Fiscal Year Final Research Report Summary
The effect of the central nervous system on apoptosis in the rat intestine
| Project/Area Number |
08670601
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Saga Medical School |
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Principal Investigator |
FUJIMOTO Kazuma Saga Med.School, Intern.Med., Prof., 医学部, 教授 (50181392)
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| Co-Investigator(Kenkyū-buntansha) |
IWAKIRI Ryuichi Saga Med.School, Intern.Med., Ass.Prof., 医学部, 講師 (70232642)
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| Project Period (FY) |
1996 – 1997
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| Keywords | hypothalamus / mucosal growth / circadian variation / cell death |
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| Research Abstract |
We previously demonstrated that the central nervous system playd an important role in the cell growth of the rat intestinal mucosa. The aim of the present study was to examine if the central nervous system had any effect on apoptosis of the intestinal mucosa in addition to the cell growth. The rate of apoptosis was evaluated by the % fragmented DNA in the mucosa. After 24 h fasting, apoptosis increased in the intestinal mucosa. Percent fragmented DNA in the ad libitum feeding rat had a circadian variation which decreased in a dark period when the rat fed. The circadian variation of the intestinal apoptosis had a mirror image of the intestinal ornithine decarboxylase activity. Administration of 2-deoxy-D-glucose into the rat third cerebroventricle tended to decrease apoptosis in the rat intestinal mucosa. This effect was, at least in part, through the lateral hypothalamus. These results suggested the possibility that the central nervous system might control apoptosis in the rat intestinal mucosa.
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