1998 Fiscal Year Final Research Report Summary
Research of Bronchial Hyperresponsiueness : with special reference to neurogenic inflammation and autonomic receptor.
| Project/Area Number |
08670648
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Akita University |
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Principal Investigator |
SHIOYA Takanobu Akita University, College of Allied Medical Science, Professor, 医療技術短期大学部, 教授 (90170852)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Masahiro Akita University, School of Medicine, Lecturer, 医学部, 講師 (20221278)
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| Project Period (FY) |
1996 – 1998
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| Keywords | Neurogenic inflammation / autonomic receptor / Bronchial hyperresponsiveness / Cough sensitivity / Capsaicin / Bronchial asthma / Eosinophil |
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| Research Abstract |
We have made bronchial asthma model using guinea pigs. We have also evaluated bronchial hyperresponsiveness by capsaicin-induced cough. In this bronchial asthma model, anti-histamine agent ; azelastine and terfenadine inhibited capsaicin-induced cough suggesting inhibition of neurogenic inflammation.
We have measured intracelular antigen EG2 in asthmatic patients using a technique in whole-blood flow cytometry. From this study, it is suggested that eosinophil intracellular EG2 is very important factor and correlates the pathophysiological condition of asthma.
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Research Products
(12 results)
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[Publications] Shioya, T., Sasaki, M., Kagaya, M., Sano, M., Shindo, T., Kashima, M., Ito, N., Miura, M.: "Cough threshold for capsaicin increases by azelastine in patients with cough variant asthma." Pulm.Pharmacol. 9. 59-62 (1996)
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「研究成果報告書概要(欧文)」より
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[Publications] Shioya, T., Kagaya, M., Sano, M., Itaba, M., Shindo, T., Miura, M.: "Bronchodilatory effect of tiquizium bromide in patients with CPOD." Eur.J.Clin.Pharmacol. 50 (5). 375-380 (1996)
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[Publications] Shioya, T., Kagaya, M., Miura, S., Shindo, T., Sano, M., Miura, M.: "Effectiveness of the anticholinergic agent in elderly patients with bronchial asthma." Arzneimittel Forschung (Drug Research). 46 (II). 1130-1133 (1996)
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[Publications] Shioya, T., Ito, N., Watanabe, A., Kagaya, M., Sano, M., Shindo, T., Miura, S., Kimura, K.: "Anti-tussive effect of azelastine hydrochrolide in patients with bronchial asthma." Arzneimittel Forschung. 48 (I). 149-153 (1998)
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「研究成果報告書概要(欧文)」より
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[Publications] Kuwasaki, T., Chihara, J., Kayaba, H., Kamata, Yumiko, Oyamada, H., Saito, N., Shioya, T., Sasaki, M., Kagaya, M., Tuda: "Whole-blood flow-cytometric analysis of eosinophil EG2 exprssion as a marker of the pathological conditions of asthma." Int Arch Allergy Immunol. 117. 77-80 (1998)
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「研究成果報告書概要(欧文)」より
