1997 Fiscal Year Final Research Report Summary
気管支喘息の気道傷害後の修復とリモデリングにおける成長因子の役割-特にトランスフォーミング成長因子β(TGFβ)を中心に-
| Project/Area Number |
08670656
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Tokyo |
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Principal Investigator |
TAKIZAWA Hajime Univ.Tokyo, Dpt.Med.Phys.Therapy, Lecturer, 医学部・附属病院, 講師 (80171578)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Makoto Univ.Tokyo, Dpt.Med.Phys.Therapy, Assist prof.of Med., 医学部・附属病院, 助手
SHOJI Shunsuke Univ.Tokyo, Dpt.Med.Phys.Therapy, Assist prof.of Med., 医学部・附属病院, 助手 (10171018)
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| Project Period (FY) |
1996 – 1997
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| Keywords | repair / remodelling / proliferation / differentiation / growth factors / TGFbeta |
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| Research Abstract |
We investiqated the potential role of a variety of growth factors in the regulation of mucosal repair and remodelling processes in the airways of asthma. Among growth factors ppssibly accumulated in the local environments of the airways, transforming growth factor-beta-1(TGFbeta-1)showed a potent inhibitory effect on the proliferation of human bronchial epithelial cells. A Th1-T cell-derived lymphokine interferon gamma also showed an inhibitory action on the cell growth. Moreover, TGFbeta-1, but not interferon-gamma, had a suppressive effect on the ciliated differentiation of human airway epithelial cells as assessed by an in vitro model of air-liquid interface culture. The megnitude of TGFbeta-1 gene expression was uprehulated in the qpithelium obtained from patients with airway inflammatory disorders including asthma as evaluated by a semiquantitative reverse transcription and polymerase reaction technique. TGFbeta-1 has been reported to stimulate airway fibroblasts to produce collagens and extracellular matrices. Taken together, therefore, it may play an important role in the repair and remodelling responses of the airways.
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[Publications] Kohyama, T., Takizawa, H., Akiyama, N., Sato, M., Kawasaki, S., Ito, K.: "A novel antiallergic drug epinas-tine inhibits IL-8 release from human e-osinophils." Biochem.Biophys.Res.Commum.230. 125-128 (1997)
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「研究成果報告書概要(和文)」より
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[Publications] Sato, M., Takizawa, H., Kohyama, T., O-htoshi, T., Takafuji, S., Kawasaki, S., Tohma, S., Ishii, A.: "Eosinophil adhesion to human bro-nchial epithelial cells:regulation by c-ytokines." Int.Arch.Allergy Immunol.113. 203-205 (1997)
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[Publications] Suzuki, N., Ohta, K., Horiuchi, T., Ta-kizawa, H., Ueda, T., Kuwabara, M., Shiga, J., Ito, K.: "T-lymphocytes and silica-induced pulmonary inflammation and fibrosis Nudeathymic mutants protect against fibrosisin mice." Thorax.51. 1036-1042 (1996)
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[Publications] Takizaw, H., Desaki, M., Ohtoshi, T., Kawasaki, S., Kohyama, T., Sato, M., Tanaka, M.: "Erythromycin modulates IL-8 expr-ession in human bronchial epithelial ce-lls:studies with normal and inflamed ai-rway epithelium." Am.J.Respir.Crit.Care Med. 156. 266-271 (1997)
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「研究成果報告書概要(和文)」より
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[Publications] Takizawa, H., Sato, M., Okazaki, H., M-atsuzaki, G., Ueda, T., Ishii, A.Shoji, S., Su-ko, M., Okudaira, H.: "Increased IL-6 and IL-8 in bronc-hoalveolar lavage fluids from patients with sarcoidosis:Correlation with the clinic-al parameters." Clin.Exp.Immunol.107. 175-181 (1997)
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[Publications] H.Takizawa, M.Desaki, T.Ohtoshi, S.Kawasaki, T.Kohyama, M.Sato, M.Tanaka, T.Kasama, K.Kobayashi, J.Nakajima, K.It: "Erythromycin modulates IL-8 expression in human bronchial epithelial cells : Studies with normal and inflamed airway epithelium." Am J Respir Crit Care Med. 156. 266-271 (1997)
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「研究成果報告書概要(欧文)」より
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