1998 Fiscal Year Final Research Report Summary
Intrapulmonary Distribution of Idiopathic and Collagen Vascular Disease associated Interstitial Pneumonia, and Local Expression of Cytokine mRNA.
| Project/Area Number |
08670658
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
SUZUKI Eiichi Niigata University Department of Medicine Associate Professor, 医学部, 助教授 (30187710)
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| Project Period (FY) |
1996 – 1998
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| Keywords | idiopathic interstitial pneumonia / collagen vascular disease associated interstitial pneumonia / intrapulmonary distribution / image analyzer / broncho-alveolar lavage / intrapulmonary cells / cell surface marker / pulmonary fibroblast |
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| Research Abstract |
The objects of this project was to clarify the difference of intrapulmonary distribution and local expression of cytokine mRNA between idiopathic interstitial pneumonia (HP) and interstitial pneumonia with collagen vascular disease (IP-CVD). There were the characteristic findings of intrapulmonary lesions of HP and IP-CVD by evaluation of chest high-resolution computed tomography and image analyzer. There was the difference in cell surface markers of lymphocyte and alveolar macrophage in broncho-alveolar lavage fluid (BALE) by FACScan between IIP and IP-CVD.And there was the difference in cytokine expression of alveolar macrophage in BALF by competitive PCR method. In this project, procollagen type I carboxyterminal propeptide levels in supernatant fluid of pulmonary fibroblast culture and serum were measured. From these results, I hope to become clear something of pathogenesis in lip and IP-CVD.
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