1996 Fiscal Year Annual Research Report

ヒトの随意運動における大脳辺縁系の関与:側頭葉てんかん手術例での多面的検討

Research Project

Project/Area Number	08670705
Research Category	Grant-in-Aid for Scientific Research (C)
Research Institution	Kyoto University
Principal Investigator	池田昭夫京都大学, 医学研究科, 助手 (90212761)
Co-Investigator(Kenkyū-buntansha)	長峯隆京都大学, 医学研究科, 助手 (10231490) 福山秀直京都大学, 医学研究科, 助教授 (90181297)
Keywords	内側側頭葉 / てんかん / 随意運動 / 準備電位 / 随伴陰性変動 / 前頭葉 / 脳電位
Research Abstract	本年度は2年計画の初年度の研究実績としてまず以下の項目に関して検討して、成果を挙げることができた。 (1)手術既施行群での準備電位の記録難治の一側性の側頭葉てんかんの患者のうち、てんかん原性焦点である一側の海馬・扁桃体の切除を施行してから6ヵ月以上経過した段階で発作が消失した患者を対象として、準備電位を頭皮上11ヵ所から記録した。左側頭葉てんかん患者群では、右手運動に先行する準備電位は左手運動に先行する電位よりCz領域で有意に振幅が低下した。年齢を一致させ健常者群ではむしろ右手運動に先行する電位が左手運動時の電位よりも大きい傾向を示したが、両運動間に有意な電位差はなかった。右側頭葉てんかん患者群では、被験者数がまだ少なく結論に至っていない。一方左外側側頭葉てんかん患者で外側側頭葉のみ切除した患者では左右の運動に先行する電位に差はなかった。以上から、少なくとも左側頭葉てんかん患者では、自己ペースによる随意運動に先行する準備電位の発生には運動と反対側の内側側頭葉の関与が示唆された。脳電位としての準備電位の記録では、開頭術による部分的な骨欠損によって頭皮上電位の分布が影響を受けるため、今回の様に骨欠損のより離れたCz領域での比較は可能だが、C3あるいはC4領域の評価は困難であった。そこで来年度は骨欠損による減衰の影響がない脳磁場計測による解析を試みる予定である。 (2)手術既施行群での随伴陰性変動の記録 (1)と同じ患者群を対象に検討を行い、感覚運動連間の立場から期待・準備・動機に関する電位を検討中である。 (3)フルオロデオキシブドウ糖によるポジトロン断層撮影法(FDG-PET) 手術施行後6ヵ月以降の時期において脳内糖代謝と手術前の計測結果と比較して、一側の扁桃体・海馬切除の影響を特に前頭葉において検討している最中である。

Research Products

(16 results)

All Other

All Publications (16 results)

[Publications] Ikeda A,et al.: "Subdural potentials at orbitofrontal and mesial prefrontal areas accompanying anticipation and decision making in humans:a comparison with Bereitschfspotential" Electroencephalography and clinical Neurophysiology. 98(3). 206-212 (1996)
[Publications] Ikeda A,et al.: "Subdural recordng of ictal DC shifts in neocortical seizures in humans." Epilepsia. 37(7). 662-674 (1996)
[Publications] Ikeda A,et al.: "Abnormal sensorimotor integration in writers cramp:study of contingent negative variation" Movement Disorders. 11(6). 683-690 (1996)
[Publications] Ikeda A,et al.: "Clinical trial of piracetam in patients with myoclonus:nationwide multi-institution study in Japan" Movement Disorders. 11(6). 691-700 (1996)
[Publications] Ikeda A,et al.: "Dissociation bewteen contingentnnegative variation(CNV) and Bereitschftaspotential(BP) in patients with parkinsonism." Electroencephalography and clinical Neurophysiology. 102(2). 142-151 (1997)
[Publications] Yazawa S,et al.: "Subdural recording of Bereitschaftspotential is useful for functional mapping of the epileptogenic motor area:a case report" Epilpsia. 38(2). 245-248 (1997)
[Publications] Mima T,et al.: "Somatosensory evoked potentials following proprioceptive stimulation in man" Experimental Brain Research. 111(8). 233-245 (1996)
[Publications] Mima T,et al.: "Afferent mechanism of cortical myoclonus studied by proprioception-related SEPs" Electroencephalography and clinical Neurophysiology. 104(1). 50-59 (1997)
[Publications] Mikuni N,et al.: ""Cavernous sinus EEG":a new method for the preoperative evaluation of temporal lobe epilepsy." Epilepsia. (in press). (1997)
[Publications] Mima T,et al.: "Modality-specific organization for cutaneous and proprioceptive sense in human primary sensory cortex studied by chronic epicortical recording" Electroencephalography and clinical Neurophysiology. (in press). (1997)
[Publications] Tachibana N,et al.: "Supplementary motor area seizure resembling sleep disorders" Sleep. (in press). (1997)
[Publications] Terada K,et al.: "Familial cortical myoclonic tremor as a unique form of cortical reflex myoclonus" Movement Disorders. (in press). (1997)
[Publications] Hamano T,et al.: "The cortical generators of the contingent negative variation in humans:a study with subdural electrodes" Electroencephalography and clinical Neurophysiology. (in press). (1997)
[Publications] Honda M,et al: "Event-related potentials during paired associate memory paradigm" Electroencephalography and clinical Neurophysiology. 100(3). 407-421 (1996)
[Publications] 池田昭夫他: "最新内科学体系65:脳の高次機能障害-てんかん-" 中山書店(荒木淑郎、金澤一郎、柴崎浩、杉田秀夫専門編集), 273-288 (1996)
[Publications] Ikeda A,et al: "Genetation of contingent negative variation in supplementary sensorimotor area:In:Advances in Neurology vol 70(Supplementary sensorimotor area)" Lippincott-Raven(H.O.Luders ed),153-159 (1996)

1996 Fiscal Year Annual Research Report

ヒトの随意運動における大脳辺縁系の関与:側頭葉てんかん手術例での多面的検討

Principal Investigator

池田 昭夫 京都大学, 医学研究科, 助手 (90212761)

Research Products

[Publications] Ikeda A,et al.: "Subdural potentials at orbitofrontal and mesial prefrontal areas accompanying anticipation and decision making in humans:a comparison with Bereitschfspotential" Electroencephalography and clinical Neurophysiology. 98(3). 206-212 (1996)

[Publications] Ikeda A,et al.: "Subdural recordng of ictal DC shifts in neocortical seizures in humans." Epilepsia. 37(7). 662-674 (1996)

[Publications] Ikeda A,et al.: "Abnormal sensorimotor integration in writers cramp:study of contingent negative variation" Movement Disorders. 11(6). 683-690 (1996)

[Publications] Ikeda A,et al.: "Clinical trial of piracetam in patients with myoclonus:nationwide multi-institution study in Japan" Movement Disorders. 11(6). 691-700 (1996)

[Publications] Ikeda A,et al.: "Dissociation bewteen contingentnnegative variation(CNV) and Bereitschftaspotential(BP) in patients with parkinsonism." Electroencephalography and clinical Neurophysiology. 102(2). 142-151 (1997)

[Publications] Yazawa S,et al.: "Subdural recording of Bereitschaftspotential is useful for functional mapping of the epileptogenic motor area:a case report" Epilpsia. 38(2). 245-248 (1997)

[Publications] Mima T,et al.: "Somatosensory evoked potentials following proprioceptive stimulation in man" Experimental Brain Research. 111(8). 233-245 (1996)

[Publications] Mima T,et al.: "Afferent mechanism of cortical myoclonus studied by proprioception-related SEPs" Electroencephalography and clinical Neurophysiology. 104(1). 50-59 (1997)

[Publications] Mikuni N,et al.: ""Cavernous sinus EEG":a new method for the preoperative evaluation of temporal lobe epilepsy." Epilepsia. (in press). (1997)

[Publications] Mima T,et al.: "Modality-specific organization for cutaneous and proprioceptive sense in human primary sensory cortex studied by chronic epicortical recording" Electroencephalography and clinical Neurophysiology. (in press). (1997)

[Publications] Tachibana N,et al.: "Supplementary motor area seizure resembling sleep disorders" Sleep. (in press). (1997)

[Publications] Terada K,et al.: "Familial cortical myoclonic tremor as a unique form of cortical reflex myoclonus" Movement Disorders. (in press). (1997)

[Publications] Hamano T,et al.: "The cortical generators of the contingent negative variation in humans:a study with subdural electrodes" Electroencephalography and clinical Neurophysiology. (in press). (1997)

[Publications] Honda M,et al: "Event-related potentials during paired associate memory paradigm" Electroencephalography and clinical Neurophysiology. 100(3). 407-421 (1996)

[Publications] 池田昭夫 他: "最新内科学体系65:脳の高次機能障害-てんかん-" 中山書店(荒木淑郎、金澤一郎、柴崎浩、杉田秀夫専門編集), 273-288 (1996)

[Publications] Ikeda A,et al: "Genetation of contingent negative variation in supplementary sensorimotor area:In:Advances in Neurology vol 70(Supplementary sensorimotor area)" Lippincott-Raven(H.O.Luders ed),153-159 (1996)

池田昭夫京都大学, 医学研究科, 助手 (90212761)

[Publications] 池田昭夫他: "最新内科学体系65:脳の高次機能障害-てんかん-" 中山書店(荒木淑郎、金澤一郎、柴崎浩、杉田秀夫専門編集), 273-288 (1996)