1997 Fiscal Year Final Research Report Summary
Thr role of human limbic structures in voluntary movements : multi-disciplinary approaches in patients with temporal lobe epilepsy
| Project/Area Number |
08670705
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
IKEDA Akio Kyoto University School of Medicine, Dpt.of Brain Pathophysilogy, Assistant Professor, 医学研究科, 助手 (90212761)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAMINE Takashi Kyoto University School of Medicine, Dpt.of Brain Pathophysilogy, Assistant Prof, 医学研究科, 助手 (10231490)
FUKUYAMA Hidenao Kyoto University School of Medicine, Dpt.of Brain Pathophysilogy, Assiociate Pro, 医学研究科, 助教授 (90181297)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Mesial temporeal structure / Epilepsy / Voluntary movements / Bereitschaftspotential (BP) / Contingent negative variation (CNV) / Frontal lobe / Electroencephalogram |
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| Research Abstract |
During the last 2 years with this financial support, we obtained new findings with regard to the following 2 aspects.
(1)Generator mechanism of slow cortical potentials in association with voluntary movements in humans
By recording contingent negative variation (CNV), which is related to externally cued movements, from subdural electrodes implanted in patients with intractable partial epilepsy, we clarified that CNV is generated non-primary motor and prefrontal cortices, in addition to primary motor cortex. It became abnormal in patients with basal ganglia dysfunction. When applying choice-reaction time paradigm in CNV task, a potential strongly related to judgment for behavior decision bacame prominent.
Slow cortical potentials preceding self-paced voluntary movements
(Bereitschaftspotential : BP) was investigated in patients with intractable left temporal lobe epilepsy after epilepsy surgery. BP with the right hand movements was significantly diminished as comapred with that with left hand movements. It strongly suggests that hyppocampus and/or amygdala plays significant role in generating BP.similar tendency was also obtained in CNV.
(2)Slow cortical potrntials in epilepsy
Ictal direct current (DC) shifts were investigated in human epilepsy by using subdural electrodes and scalp electrodes. Subdurally recorded ictal DC shifts were clinically useful to more specify an epileptogenic area. Multidisciplinary, electrophysiological studies of human cerebral cortices by subdural electrodes in epilepsy patients could clarify normal cortical functions in detail, that aided presurgical evaluation.
(3)Future plans
Based on the obtained findings as described above, further approaches for generator mechanism of BP, CNV and ictal DC shifts are exptected especially from the view points of magnetic brain activity, and clinical application of those brain activities are also highly expected.
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