1997 Fiscal Year Final Research Report Summary
Changes of cortical potentials preceding voluntary movements in a subacute stage of hemiparesis
| Project/Area Number |
08670729
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Teikyo University School of Medicine |
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Principal Investigator |
SHIMIZU Natsue Teikyo Univ.Sch.of Med., Dept.of Neurology, Professor, 医学部, 教授 (80095017)
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| Project Period (FY) |
1996 – 1997
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| Keywords | plasticity / hemiparesis / readiness potential / cortical potential / voluntary movement / recovery / Bereitshaftspotential |
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| Research Abstract |
We investigated the neurophysiological evidence of brain plasticity and its effect on the recovery from a hemiparesis.
Seventeen patients with a hemiparesis due to a single and recent episode of cerebrovascular accident (CVA) were examined. Cortical potentials (readiness potentials, RP) preceding voluntary finger flexion were recorded in 4 to 60 days after CVA and motor weakness was graded at the time of the recording and 6 months after the CVA.The late component of the RP was larger on the contralateral hemisphere to the finger in 12 patients out of 17 and larger on the ipsilateral hemisphere in none on the normal finger movements. In contrast, the RP was larger on the contralateral hemisphere to the finger in 6 patients, and larger on the ipsilateral hemisphere in 5 patients on paretic finger movements. The early and late components of the RP on the midline was larger on paretic finger movements than normal finger movements in 5 and 2 patients respectively. The early and late components of the RP was larger on normal finger movements than paretic finger movements in 4 and 3 patients respectively. The ipsilateral activation of the RP to a paretic finger and the activation of the RP on paretic finger movements did not affect the recovery of the hemiparesis.
In conclusion, the RP of an ipsilateral hemispere was frequently larger than that of an contralateral hemisphere to a hemiparesis in paretic finger movements. The degree of recovery from a hemiparesis was not affected by the presence of an ipsilateral preponderance of the RP on sensorimotor cortices. The RP of the patients with a recent stroke strongly suggests a neurophysiological evidence of plasticity of the adult brain.
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