Anti-neural calcium channel antibodies in amyotrophic lateral sclerosis

1998 Fiscal Year Final Research Report Summary

• Project/Area Number: 08670736
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Osaka Medical College
• Principal Investigator: FURUTAMA Daisuke Faculty of Medicine, Osaka Medical College, Stuff, 医学部, 助手 (70291987)
• Co-Investigator(Kenkyū-buntansha): TSUJI Kuniko Osaka Medical College, Reseach fellow, 医学部, 専攻医 ; TAGAMI Muneyoshi Osaka Medical College, Reseach fellow, 医学部, 専攻医 ; NAKAJIMA Hideto Osaka Medical College, Reseach fellow, 医学部, 専攻医 ; ITO Takumi Osaka Medical College, Reseach fellow, 医学部, 専攻医 ; SHINODA Keiichi Osaka Medical College, Assistant professor, 医学部, 講師 (60187367)
• Project Period (FY): 1996 – 1998
• Keywords: amyotrophic lateral aclerosis / motoneuron / calcium channel / autoantibody / cell death

Research Abstract

It was recently suggested that anti-voltage-gated calcium channel (VGCC) antibody in patients with amyotrophic lateral sclerosis (ALS) could enhance Ca2+ current and cause neuronal cell death. Although more than six distinct subtypes of al subunit of VGCC have been known, it has not been shown directly which neuronal type of al subunit is the target of antibodies in ALS, In this study, using type specific anti-al subunit antibodies, we tried to reveal al subtypes, to which antibodies in ALS serum bind. Anti-VGCC antibodies are positive in 25 to 65% of patients. The heterogeneity of anti-al subumt of VGCC antibodies in ALS serum was shown. Because type-specificity for antibodies vary among patients, contributions of these antibodies to ALS pathophysiology may differ with individual patients.

Research Products

• [Publications] Nakajima-H.et al.: "Analysis of transcriptional regulation of the androgen receptor in X-linked spinal and bulbar muscular atrophy." J.Neurological Science. 142. 12-16 (1996)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Nakajima-H.et al.: "Effects of androgen receptor polyglutamine tract expansion on proliferation of NG 108-15 cells" Neuroscience Letters. 222. 83-86 (1997)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] 木村文治: "抗カルシウムチャンネル抗体(in"キーワード1997-98神経変性疾患")P11-12" 先端医学社, 2 (1997)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Kimura-F.et al.: "("Amyotrophic Lateral Screlosis") The Specific Antibody Against α1 Subunit of L-type Ca^<2+> Channel in Sporadic ALS." Elsevier, 4 (1996)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Hideto Nakajima, Fumiharu Kimura, Toshimasa Nakagawa, Daisuke Furutama, Keiichi Shinoda, Akira Shimizu, Nakaaki Ohsawa: "Analysis of transcriptional regulation of the androgen receptor in X-linked spinal and bulbar muscular atrophy" J Neurological Science. 142. 12-16 (1996)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Hideto Nakajima, Fumiharu Kimura, Toshimasa Nakagawa, Toshiyuki Ikemoto, Daisuke Furutama, Keiichi Shinoda, Shigeaki Kato, Akira Shimizu, Nakaaki Ohsawa: "Effects of androgen receptor polyglutamine tract expansion on proliferation of NG108-15 cells." Neuroscience Letters. 222. 83-86 (1997)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Fumiharu Kimura, Glenn Smith, Osvaldo Delbono, Okot Nyormoi, Toni Schneider, Wolfgang Natainczyk, Franz Hofmann, Enrico Stefani, Stanley H.Appel.: The specific antibody against alpha1 subunit of L-type Ca2+ channel in sporadic ALS.(in Amyotrophic Lateral Sclerosis : Progress and Perspective in Basic Research and Clinical Application). Elsevier, Amsterdam, (1996)
  • Description: 「研究成果報告書概要(欧文)」より