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1998 Fiscal Year Final Research Report Summary

Immunologic mechanisms for outgrowing mite-sensitive bronchial asthma

Research Project

Project/Area Number 08670911
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKITASATO UNIVERSITY

Principal Investigator

NOMA Takeshi  Kitasato University, School of Medicine Assistant Professor, 医学部, 講師 (60208387)

Co-Investigator(Kenkyū-buntansha) YATA Junichi  Tokyo ikashika University School of Medicine Professor, 医学部, 教授 (60057502)
Project Period (FY) 1996 – 1998
Keywordsmature B Cell lines secreting Dermatophagoides farinae (Df)-specific IgE / IL-10 / G-CSF / IL-12 / outgrowing mite-sensitive bronchial asthma / Df-specific Th0 cell clones / apoptosis / RS virus infection / cytokine inbalance / high dose IL-12 induces Th2 or Th0 responses
Research Abstract

We investigated immunologic mechanisms for outgrowing mite-sensitive bronchial asthma. In order to disclose the regulatory mechanisms in production of antigen-specific IgE in human systems we successfully established lines secreting Dermatophagoides farinae (Df) -specific IgE from peripheral mononuclear cells extracted from a patient with mite-sensitive asthma by immortalization with the Epstein-Barr virus. To advance the studies, we investigated (1) Immunologic mechanisms in onset of allergic deseases, (2) Natural outgrowing bronchial asthma, (3) Immunopharmacologic mechanisms of anti-allergic agents and relationships with the outgrowing bronchial asthma, and then (4) established human B cell lines secreting Dermatophagoides farinae-specific IgE and analyzed its regulatory mechanisms by inflammatory cytokines and soluble factors derived from T cell clones in patients with bronchial asthma in remission : it is likely that IL 10 triggers positive feedback mechanism in the IgE production in patients with bronchial asthma, resulting in the prolongation of asthmatic attack ; granulocyte-colony stimulating factor (G-CSF) augments the Df-specific IgE production by the activated mature B cells on stimulation of CD40 molecules, and assists IL-4, IL-13 or growth hormone (GH) function to increase the IgE production. JFN-γ or a low, but not a high, dose of IL-12 regulates these increased activities of the IgE ; The balance of apoptotic cell induction and IgE augmentation in mature B cells secreting Df-specific IgE by Df-specific T cell clones was likely involved in the clinical conditions in mite-sensitive asthma patients in remission. The factor (s) inducing apoptosis could contribute to treatment of bronchial asthma.
We believe that outcomes of our study result in curative treatment of bronchial asthma.

  • Research Products

    (37 results)

All Other

All Publications (37 results)

  • [Publications] Kawano Y: "Inhibition by lecithin-bound iodine(LBI) of inducible allergen-specific T lymphocytes' responses in allergic diseases"International Journal of Immunopharmacology. 18(4). 241-249 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawano Y: "Role of interleukin-2 and interferon-gamma in inducing production of IgG subclasses in lymphocytes of human newborns"Immunology. 88(1). 40-48 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noma T: "Induction of allergen-seciffL-2 responsiveness of lymphocytes after respiratory syncytial virus infection and prediction of onset of recurrent wheezing and bronchial asthma"Jounal of Allergy & Clinical Immunology. 98(4). 816-826 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noma T: "Cytokine production in children outgrowing hen egg allergy"Clinical & Experimental Allergy. 26(11). 1298-1307 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noma T: "T cell mediation of abnormally low production of ovalbumin-specific immunoglobulin A in patients allergic to eggs"Rediatric Research. 39(2). 329-335 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noma T: "Reduced IL-1 production in adolescents with mite antigen asthma in remission"Clinical & Experimental Immunology. 113(1). 10-16 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noma T: "Effect of oxatomide on T-cell activation and the production of interferon-gamma in mite sensitive"European Journal of Pharmacology. 343(2-3). 239-247 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noma T: "Functional Interleukon-5 activity in peripheral blood monomucler cells form adolescents with mite antigen asthma in remission"Clinical Experimental Allergy. 29. 780-785 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noma T: "A comparative investigation of tha restorative effects of roxithromycin on neutrophil activities"International Journal of Immunopharmacology. 20. 615-624 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noma T: "Correlation between antigen-specific IL2 response test and provocation test for egg allergy in atopic dermatitis"Clinical & Experimental Allergy. 28. 1120-1130 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noma T: "Interleukin-12 affects Dermatophagoides farinae (Df)-induced interleukin-4 production by T cells form pediatric patients with mite-sensitive asthma"Jounal of Allergy & Clinical Immunology. 103(5). 850-858 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noma T: "Establishment of B cell lines secreting Dermatophagoides fornae-specific IgE and enhancement by inerleukin-10"(submitted). (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noma T: "Modulatin of apoptotic cell induction in a mature B clone secreting Dermatophagoides-specific IgE by T cell clones form a patient with bronchial asthma in remissin"(submitted). (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noma T: "Granulocyte colony-stimulating factor enhances Dermatophagoides antigen-specific LgE secretion by mature B cell clones and the regulation by LFN-γ and IL-12"(submitted). (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 野間剛: "気管支喘息小児におけるダニ抗原活性化T細胞の与える漢方方剤 ; 柴朴湯、小青竜湯、及び柴苓湯の比較検討(総説)"漢方と免疫アレルギー. 10(12). 90-101 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 野間剛: "リンパ球・APC機能の in vitro検査 抗体産生能(総説)"臨床免疫. 28. 219-223 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 野間剛: "特集: アトピー児に対する early intervention/ アレルゲン感作の始まりとその診断(総説)"アレルギーの臨床. 17(11). 831-835 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 野間剛: "小児アレルギーのすべて IIアレルギーとアルゲンの診断・検査/サイトカイン測定(総説)"小児診断. 61. 146-153 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 野間剛: "解説、思春期喘息の病態(総説)"アレルギー科. 7(5). 438-447 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 野間剛: "食物アレルギーとIL-12. In : アレルギーとサイトカイン"医薬ジャーナル社(東京) 上野川修一,近藤直美 (ed). 15 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 野間剛: "リンパ球機能. In : アレルギー検査法"医薬ジャーナル社(東京) 宮本昭正,石川●,飯倉洋治 (ed). 6 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 野間剛: "小児喘息の成長による変化とその原因. In : 気管支喘息治療の最前線"克誠堂(東京) 伊藤幸治 (ed). 8 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 野間剛: "アレルギーとサイトカイン(概説). In : アレルギー疾患イラストレイテッド"メヂカルレビュー社(東京) 森田寛,永倉俊和 (ed). 8 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawano Y: "Inhibition by lecithin-bound iodine (LBI) of inducible allergen-specific T lymphocytes' responses in allergic diseases"International Journal of lmmophamacology. 18 (4). 241-249 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawano Y: "Role of interleukin-2 and interferon-gamma in inducing production of IgG subclasses in lymphocytes of human newborns"Immunology. 88 (1). 40-48 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noma T: "Induction of allergen-specific IL-2 responsiveness of lymphocytes after respiratory syncytial virus infection and prediction of onset of recurrent wheezing and bronchial asthma"Journal of Allergy & Clinical Immunology. 98 (4). 816-826 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noma T: "Cytokine production in children outgrowing hen egg allergy"Clinical & Experimental Allergy. 26 (11). 1298-1307 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noma T: "T cell mediation of abnormally low production of ovalbumin-specific immunoglobulin A in patients allergic to eggs"pediatric Research. 39 (2). 329-335 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noma T: "Reduced IL-1 production in adolescents with mite antigen asthma in remission"Clinical & Experimenta Immunology. 113 (1). 10-16 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noma T: "Effect of oxatomide on T-cell activation and the production of interferon-gamma in mite sensitive asthma"European Journal of' Pharmacology. 343 (2-3). 239-247 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noma T: "Functional Interleukin-5 activity in peripheral blood mononuclear cells from adolescents with mite antigen asthma in remission"Clinical Experimental Allergy. 29. 780-785 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noma T: "A comparative investigation of the restorative effects of roxithromycin on neutrophil activities"International Journal of lmmophamacology. 20. 615-624 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noma T: "Correlation between antigen-specific IL2 response test and provocation test for egg allergy in atopic dermatitis"Clinical Experimental Allergy. (28). 1120-1130 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noma T: "nterleukin-12 affects Dermatophagoides farinae (Df)-induced interleukin-4 production by T cells from pediatric patients with mite-sensitive asthma"Journal of Allergy & Clinical Immunology. 103 (5). 850-858 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noma T: "Establishment of B cell lines secreting Dermatophagoides farinae-specific IgE and enhancement by interleukin-10"(submitted). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noma T: "Modulation of apoptotic cell induction in a mature B cell clone secreting Dermatophagoides-specific IgE by T cell clones from a patient with bronchial asthma in remission"(submitted). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noma T: "Granulocyte colony-stimulating factor enhances Dermatophagoides antigen-specific IgE secretion by mature B cell clones and the regulation by IFN-γ and IL-12"(submitted). (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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