1997 Fiscal Year Final Research Report Summary
The Consteuction of the animal model for CTCL by SCID mouse
| Project/Area Number |
08670963
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
TACHIBANA Takao Kyoto University, Post graduate School of Medicine, Instructor., 医学研究科, 助手 (40179718)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Toshihiro Kyoto University, Post graduate School of Medicine, Lecture, 医学研究科, 講師 (50188314)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Mycosis Fungoides / CTCL / SCID mouse / Adult T cell leulcrmia / animal model / epidermotropism / Pautrie's abscess / colony formation |
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| Research Abstract |
Mycosis fungoides is a cutaneous T cell lymphoma with clinical characteristics of epidermal manifistation. It starts as an erythematous stage which shoes poor malignancy and progress to the tumor stage and finaly kills the host. There was no experimental animal model of this disease, thus it was difficult to constract an experimental procedure for the analysis of pathomechanism of this disease for the experimental treatment model in the animals. Our purpose was the establishment of an animal model by modify of ATL model in the SCID mouse. The malignant T cell from the Mycosis Fungoides patient skin was injected intravenous in the SCID mouse. The transplanted malignant T cell survive in the SCID mouse. Colony formations were observed in the lymphnodes, liner, spleen and skin. The skin lesion was not constracted with simple mass formation in the dermis, but it showed the epidermotropism. Pautrie's microabcess which is a histopathological character of Mycosis Fungoides was also abserved in thei animal model. From these data, we concluded that this animal model mimic the Mycosis Fungoides.
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