1998 Fiscal Year Final Research Report Summary
Pathogenesis and classification of acquired epidermolytic hyperkeratosis
| Project/Area Number |
08670987
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nihon University |
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Principal Investigator |
SUZUKI Hiroyuki Nihon Univ.School of Med.Dermatol.Dept.Professor, 医学部, 教授 (40059473)
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| Project Period (FY) |
1996 – 1998
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| Keywords | epidermolytic hyperkeratosis / acquired / Keratin 1 / Keratin 2 / K1 gene / K10 gene / mutation / sun exposure |
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| Research Abstract |
Epidermolytic hyperkeratosis (EH) is a distinctive histologic feature of various congenital and acquired dermatoses. In some congenital keratinizing disorders manifesting EU, the keratin filament abnormality involves K1 and K10, and it is known that EU arises from mutations in the genes for K1 and K10. However, there are few reports on the abnormalities of keratin filaments in acquired EH.Persistent actinic epidermolytic hyperkeratosis (PAEH), which tends to appear after excessive sun exposure, and which we have suggested is one type of acquired EH, but keratin filament abnormalities have not been reported. The purpose of this study was to examine keratin expression to elucidate keratin filament abnormalities. Expression of various keratins was observed in PA.EH using immunocytochemistry, and positive results were obtained for K1 and K10 in the EH lesion of EH in PAEU with light microscopy. Strong positive reactions for K and K10 were seen in abnormally aggregated tonofibrils with electron microscopy. In conclusion, K1 and Kl0 abnormalities were found in aggregated tonofibrils of PAEH lesions. It is suspected that ELI in PABH may result from mutations in K1 and K10 genes because of excessive sun exposure. Acquired EH is usually involved in epidermolytic acanthoma. Elowever, the findings obtained indicate that PAEH is independent of epidermolytic acanthoma.
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