1997 Fiscal Year Final Research Report Summary
DRUGMONITORING OF ANTI-CANCER DRUG USING RADIONUCLIDES -APPLICATION FOR TDM OF MULTI-DRUG CHEMOTHERAPY-
| Project/Area Number |
08671006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | GUNMA UNIVERSITY |
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Principal Investigator |
INOUE Tomio GUNMA UNIVERSITY SCHOOL OF MEDIClNE ASSOCIATE PROFESSOR, 医学部, 助教授 (80134295)
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| Co-Investigator(Kenkyū-buntansha) |
TOMIYOSHI Katsumi UNIVERSITY SCHOOL OF MEDIClNE FELLOW, 医学部, 助手 (60188802)
ENDO Keigo GUNMA UNIVERSITY SCHOOL OF MEDICINE PROFESSOR, 医学部, 教授 (10115800)
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| Project Period (FY) |
1996 – 1997
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| Keywords | RADIONUCLIDES / TDM / MULTIDRUG CHEMOTHERAPY / ANTI-CANCER DRUG / CANCER TREATMENT |
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| Research Abstract |
The aim of this research was as follows :
1) Development of ^<111>In labeled Adriamycin as a new agent
2) Research of ^<111>In labeled Taxol using tumor bearing mice
3) Experiment of ^<123>I-EU using tumor bearing mice
4) Research of radiosynthesis of ^<111>In-Tamoxifen and experimental evaluation of its biodistribution
5) Research of radiosynthesis of ^<18>F-5FU and experimental evaluation of its biodistribution
Radiosynthesis of five different radiolabelled anticancer drugs as described above was succeeded and the biodistribution of ^<111>In labeled Taxol, ^<123>I-EU,and^<18>F-5FU were assessed using tumor bearing mice. The relationships between the concentration of radiolaballed anticancer drugs and the effectiveness on tumor-response of corresponding ant-cancer drugs were not clear. However results of biodistribution obtained in this study encouraged us to use the radiolabelled anti-cancer drugs clinically.
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