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1998 Fiscal Year Final Research Report Summary

Analysis of mechanism for enhanced iodine uptake in thyrocytes by interferons

Research Project

Project/Area Number 08671023
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

MISAKI Takashi  Kyoto University Graduate School of Medicine, Nuclear Medicine and Diagnostic Imaging, Instructor, 医学研究科, 助手 (60181872)

Co-Investigator(Kenkyū-buntansha) KASAGI Kanji  Kyoto University Graduate School of Medicine, Nuclear Medicine and Diagnostic Im, 医学研究科, 助教授 (20115819)
Project Period (FY) 1996 – 1998
Keywordsinterferons / thyrocytes / staurosporine / protein kinase C / iodine
Research Abstract

In rat thyroid cell line FRTL5, thyroid stimulating hormone (TSH) stimulated protein kinase C (PKC) measured by binding of phorbol-dibutylate. Interferon (IFN) gamma dose dependently suppressed this stimulation. The suppression was reproduced by non-gamma IFN, and potentiated by tumor necrosis factor. On the other hand, inhibitors of PKC such as staurosporine, H-7, and H-9 stimulated iodine uptake in TSH-deprived FRTL5 cells, additive to IFN-driven enhancement. The 3 PKC inhibitors suppressed TSH stimulation of iodine uptake, while IFN act synergistically with TSH in this regard. The results imply IFN inhibits PKC activity via mechanisms different from that of other inhibitors.

  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Misaki, T. et al.: "Unasual extrathyroidal uptake." Journal of Nuclear Medicine. 39; 9. 5A-1650 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Misaki, et al.: "Binding of a human monoclonal on tithyroglobulin antibody to cultured human thyroid cencer cells." Annals of Nuclear Medicine. 11. 81-85 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 御前 隆 他: "放射性ヨード療法の著効例" 免疫腫瘍核医学. 12. 60-61 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 御前 隆 他: "インターフェロンによる甲状腺癌のヨード摂取増強作用" 映像情報MEDICAL. 28. 1256-1259 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 御前 隆: "核医学ハンドブック(小西淳二編; RI内用療法の章)" 金芳堂, 15 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Misaki, T,et al.: "Unusual extrathyroidal uptake." Journal of Nuclear Medicine. 39-9. 5A-1650 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Misaki, T,et al.: "Binding of a human monoclonal antithyroglobulin antibody to cultured human thyroid cancer cells." Annals of Nuclear Medicine. 11-2. 81-85 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Misaki, T,et al.: "Complete remission of lung metastasis from thyroid cancer after I-131 therapy : A case report." Journal of Oncological Nuclear Medicine. 12-2. 60-61 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Misaki, T,et al.: "Enhancement by interferons of iodine uptake in cultured thyroid cancer cells." Journal of Medical Imaging and Information. 28-12. 1256-1259 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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