1997 Fiscal Year Final Research Report Summary

Research for Dopaminergic Neurotransmission Using Positron Emission Tomography

Research Project

Project/Area Number	08671037
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Radiation science
Research Institution	Kyushu University
Principal Investigator	KUWABARA Yasuo Faculty of Medicine, Kyushu University Associate Professor, 医学部, 助教授 (30150436)
Co-Investigator(Kenkyū-buntansha)	NAKAGAWA Makoto Faculty of Medicine, Research Associate, 医学部, 医員 YOSHIDA Tsuyoshi Faculty of Medicine, Research Associate, 医学部, 助手 (40284509) FUKUMURA Toshimitsu Faculty of Medicine, Research Associate, 医学部, 助手 (90199266) SASAKI Masayuki Faculty of Medicine, Research Associate, 医学部, 助手 (40240907)
Project Period (FY)	1996 – 1997
Keywords	positron emission tomography / dopamin D_2 receptor / C-11 raclopride / effect of normal aging / Parkinson's disease
Research Abstract	We developed a synthesis system for production of C-11 raclopride, and measured dopamine D2 receptor in normal volunteers and patients with Parkinsonian symptoms. The subjects consisted 10 normal volunteers and 4 patients, including 2 patients with striatonigral degeneration, one patient with corticobasal degeneration and Parkinson's disease. 7.9 - 22.4 mCi of C-11 raclopride was intravenously administered as a bolus. The data were collected for every 2 min (0-20 min), every 4 min (20-60 min) and 15 min (63-78 min). Striatal C-11 raclopride uptake was evaluated by the equilibrium method with individually determined plateau time. We used the cerebellum as a reference region of non-specific binding site. There was no significant effect of C-11 raclopride specific activity on the striatal/cerebellar uptake ratio in a range of 378 to 1800 mCi/ mu mol. In normal volunteers, the striatal/cerebellar uptake ratio gradually decreased with age at a rate of 0.5 %/year. The striatal/cerebellar uptake ratio decreased in a patient with striato-nigral degeneration and a patient with corticobasal degeneration. It was preserved in a patient with striatonigral degeneration and a patient with Parkinson's disease. C-11 raclopride is thought to be useful for evaluating D_2 receptor in patients with Parkinsonian symptoms.