1997 Fiscal Year Final Research Report Summary
EVALUATION OF ACCURACY OF SPECT IN THE DIAGNOSIS OF BRAIN TUMOR
| Project/Area Number |
08671048
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | SAITAMA MEDICAL SCHOOL |
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Principal Investigator |
MACHIDA Kikuo SAITAMA MEDICAL SCHOOL,FACULTY OF MEDICINE,PROFESSOR, 医学部, 教授 (40010235)
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| Co-Investigator(Kenkyū-buntansha) |
HOSONO Makoto SAITAMA MEDICAL SCHOOL,FACULTY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (00281303)
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| Project Period (FY) |
1996 – 1997
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| Keywords | IMAGE DATA BASE / BRAIN TUMOR / T1-201 SPECT / MRI / ROC curve / reading experiment / variance among doctors |
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| Research Abstract |
Fifteen-four studies of ^<20l>T1 brain tumor SPECT were independently interpreted by 9 nuclear medicine physicians with and without reference magnetic resonance images in 2 separate sessions to define an effect of referring images, and inter-observer variations. The physicians were requested to detect foci of abnormal deposits, and to discriminate whether they were malignant or not according to 5-grade scaling of subjective diagnostic confidence. Receiver-operating characteristics (ROC) analysis was performed. Mean sensitivity for presence of lesions (SFP), and sensitivity and specifcity for malignancy of ^<201>T1 SPECT were 84, and 53 and 55%, which were changed to 94, and 74 and 55% after referring to the MR images. The SFP was significantly improved (p<0.05), but sensitivity and specificity for malignancy, assessed by areas under the ROC curves, were not significantly improved. Inter-observer variation of the SFP was significantly reduced with addition of the referring MR images. Cerebral lobar localization of lesions by SPECT showed great inter-observer variations (true localization ranged from 30 to 68.4%). It is concluded that ^<201>T1 brain tumor SPECT has moderate sensitivity and specificity for malignancy, which is not improved by addition of anatomical reference images, that additional MR images reduce inter-observer variation of confidence on lesion presence, and that SPECT localization of lesions has great inter-observer variations.
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