1997 Fiscal Year Final Research Report Summary
Increased Technetium-99m-GSA Uptake per Hepatocyte in Rats with Administration of Dimethylnitrosamine or Hepatocyte Growth Factor
| Project/Area Number |
08671059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kansai Medical University |
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Principal Investigator |
HA-KAWA Sang Kil KANSAI MEDICAL UNIVERSITY,FUCULTY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (30152896)
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| Co-Investigator(Kenkyū-buntansha) |
MURATA Takashi KANSAI MEDICAL UNIVERSITY,FUCULTY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (50121992)
NAKANO Yoshihisa KANSAI MEDICAL UNIVERSITY,FUCULTY OF MEDICINE,ASSOCIATE PROFESSOR, 医学部, 助教授 (70115898)
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| Project Period (FY) |
1996 – 1997
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| Keywords | technetium-99m-GSA / asialoglycoprotein receptors / hepatocyte growth factor / dimethylnitrosamine |
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| Research Abstract |
In the DMN-treated rats the total number of hepatocytes and GSA plasma clearance were reduced significantly at 3 weeks after the final administration of DMN.However, calculated GSA uptake per individual hepatocyte was significantly greater by 53.2% than in the normal controls. The area of liepatic nucleus was also significantly greater than in the normal controls. In the rhHGF-treated rats an increase in the total number of hepatocytes was not demonstrated on the final day of rhHGF administration (day 4). However, calculated GSA uptake per hepatocyte was significantly greater by 59.0% than in the controls. Conclusion : Augmented GSA uptake per hepatocyte during the convalescent stage after hepatic injury suggests a cellular compensation to the decreased number of hepatocyte. This mechanism may be caused by the secretion of some hepatotropic factors such as hepatocyte growth factor.
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[Publications] Ha-Kawa SK, Tanaka Y, Hasebe S, Kuniyasu Y, Ishii Y, Yamamoto K, Kashiwagi T, Ito A, Kudo M, Ikekubo K, Tsuda T, Murase K.: "Compartmental Analysis of Asialoglycoprotein Receptor Scintigraphy for Quantitative Measurement of Liver Function : A Multicentre Study." E J Nucl Med. 24. 130-137 (1997)
Description
「研究成果報告書概要(欧文)」より
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