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1997 Fiscal Year Final Research Report Summary

Effects of coordinated stimulations triggered by interictal discharges on kindling-induced epileptogenesis.

Research Project

Project/Area Number 08671114
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionSOKA UNIVERSITY

Principal Investigator

KOGURE Shinichi  Soka Univ.Dept.Bioengn.Associate Prof., 工学部, 助教授 (10133448)

Project Period (FY) 1996 – 1997
Keywordshippocampus / kindling / interictal discharge / epileptogenesis / afterdischarge threshold
Research Abstract

It is generally accepted that kindling-induced interictal discharges (IIDs) are almost similar to IIDs of epileptic patients. However, their general characteristics, i.e., whether they reflect an excitatory event or an inhibitory one and how they are generated, are still unknown. In previous studies, we classified kindling-induced IIDs into three types : simple A,simple B and complex. The complex type consisted of two-three simple IIDs, and its frequency was associated with the development of behavioral responses during kindling.
The present experiment was designed to reveal effects of coordinated stimulations triggered by IIDs on epileptogenes induced by hippocampal kindling of the rabbits. Out of 17 animals, ten developed stage 5 convulsions with a mean of 19 stimulations (K group), whereas the remaining did not (IK group). Before daily kindling stimulation, a coordinated stimulation, which was a miniature type of kindling stimulation either driven at random (RS) or triggered by the I … More ID (TS), was applied to generate an afterdischarge while changing stimulus parameters. The final stimulus intensity (voltage*frequency*no.of train) was standardized based on those of kindling and referred to as a standard intensity index (SII). In K group, averaged SIIs were 28(]SY.+-。[)3% (when the stimuli were triggered by simple A type of IIDs : n=7), 32(]SY.+-。[)4% (simple B : n=16) and 39(]SY.+-。[)4% (complex : n=24), while it was 38(]SY.+-。[)5% when applied at random (n=79). Those of IK group were 48(]SY.+-。[)5% (simple A : n=11), 75(]SY.+-。[)4% (simple B : n=4), 42(]SY.+-。[)3% (complex : n=10) and 55(]SY.+-。[)5% (at random : n=52), respectively. The SII differences between TS and RS were -10 to -7% (simple A), -6 to +20% (simple B) and -23 to +1% (complex). Since negative values indicate weaker stimuli to generate afterdischarges than RS intensity whereas positive values do stronger ones, it is concluded that simple B type of IIDs has suppressive effect on seizure susceptibility while simple A and complex IIDs have facilitatory effect. Less

  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] KOGURE, S., et al.: "INTERICTAL DISCHARGES DURING HIPPOCAMPAL KINDLING OF THE RABBIT:STIMULANT OR SUPPRESSOR?" Jpn.J.Physiol.Vol.46 Suppl.s.150 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinichi Kogure, et al.: "EFFECTS OF COORDINATED STIMULATIONS TRIGGERED BY INTERICTAL DISCHARGES ON THE HIPPOCAMPAL KINDLIMNG" Abstracts of Inaugural Congress of Asian and Oseanian Epilepsy Organization.39 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yukiko Wada, et al.: "FACILITATORY EFFECT OF INTERICTAL DISCHARGES ON THE EPILEPTOGENESIS DURING HIPPOCAMPAL KINDLING" Epilepsia. Vol.37 Suppl.5. 74 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinchi Kogure, et al.: "DENDRITIC ACTIVITIES CORRESPONDING TO INTERICTAL DISCHARGES INDUCED BY HIPPOCAMPAL KINDLING" Epilepsia. Vol.37 Suppl.5. 76 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木暮 信一, 浦田 靖夫, ほか: "海馬キンドリングにおける発作間欠期スパイクと樹状突起電気活動との関連性." 『てんかん研究』. Vol.15.No.1. 35 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinichi Kogure, et al.: "Relationship between kindling-induced interictal discharges and pyramidal dendritic activities in the rabbit hippocampus." Epilepsia. Vol.38 Suppl.6. 58 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinichi Kogure: "Properties of interictal discharges induced by hippocampal kindling." Epilepsy Research. Vol.27. 139-148 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kogure: "Characteristics of interictal discharges induced by kindling of the rabbit hippocampus." Ann.Rep.Jpn.Epil.Res.Found.Vol.9. 24-31 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kogure, at al.: "Effects of local anaesthesia on kindling-induced interictal discharges." Epilepsia. Vol.38 Suool.3. 176 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木暮 信一: "ウサギ海馬のキンドリング形成過程で発現する発作間次期スパイクの特性." 第9回てんかん治療研究振興財団・研究報告会抄録集. 47-48 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Oshida, et al.: "Characteristics of interictal discharges induced by hippocampal kindling of rabbits." Jpn.J.Physiol.Vol.47 Suppl.2. s.241 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Wada, et al.: "Synchronization of simple type of interictal discharges during hippocampal kindling." Jpn.J.Physiol.Vol.47 Suppol.2. s.241 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木暮 信一, 浦田 靖夫, ほか: "発作間欠期スパイクと電気刺激の組合せによるキンドリング形成過程の検討." てんかん研究. Vol.16 No.1. 54 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kogure, et al.: "Interictal discharges during hippocampal kindling of the rabbit : Stimulant or suppressor?" Jpn.J.Physiol.vol.46, suppl.150 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kogure, et al.: "Effects of coordinated stimulations triggered by interictal discharges on the hippocampal kindling." Abstracts of Inaugural Congress of Asian and Oseanian Epilepsy Organization.39 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Wada, et al.: "Facilitatory effect of interictal discharges on the epileptogenesis during hippocampal kindling" Epilepsia. vol.37, suppl.5. 74 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kogure, et al.: "Dendritic activities corresponding to interictal discharges induced by hippocampal kindling." Epilepsia. vol.37, suppl.5. 76 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kogure, et al.: "Relationship between kindling-induced interictal discharges and pyramidal dendritic activities in the rabbit hippocampus." Epilepsia. vol.38, suppl.6. 58 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kogure: "Properties of interictal discharges induced by hippocampal kindling." Epilepsy Res.vol.27. 139-148 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kogure: "Characteristics of interictal discharges induced by kindling of the rabbit hippocampus." Ann.Rep.Jpn.Epil.Res.Found.vol.9. 24-31 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kogure, et al.: "Effects of local anaesthesia on kindling-induced interictal discharges." Epilepsia. vol.38, suppl.3. 176 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Oshida, et al.: "Characteristics of interictal discharges induced by hippocampal kindling of rabbits." Jpn.J.Physiol.vol.47, suppl.2. 241 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Wada, et al.: "Synchronization of simple type of interictal discharges during hippocampal kindling." Jpn.J.Physiol.vol.47, suppl.2. 241 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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