1997 Fiscal Year Final Research Report Summary
Phenotypically changed mesangial cells glomerulosclerosis associated with hyperlipidemia in primary FSGS.
| Project/Area Number |
08671306
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tokyo Women's Medical College |
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Principal Investigator |
HATTORI Motoshi Tokyo Women's Medical College, Medicine, Lecture, 医学部, 助手 (50192274)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Yutaka Tokyo Women's Medical College, Medicine, Assistant Professor, 医学部, 助教授 (60057073)
YOSHIOKA Yoshimasa Tokyo Women's Medical College, Medicine, Assistant Professor, 医学部, 助教授 (60146438)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Nephrotic Syndrome / Hyperlipidemia / Renal injury / Glomerulosclerosis / Mesangial cell / Phenotypic change / Macrophage / Focal segmental glomerulosclerosis |
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| Research Abstract |
Patients with steroid-resistant nephroric syndrome due to primary focal segmental glomerulosclerosis (FSGS) have a grave prognosis. The purpose of this study was to examine the pathological role of phenotypically changed mesangial cells in the process of glomerulosclerosis in primary FSGS.The results of this study indicate that 1) mesangial cells undergo phenotypic changes to myofibroblasts, 2) phenotypically changed mesangial cells to myofibroblast participate in the active scarring by de novo synthesis of interstitial collagens, and 3) growth factors originating from infiltrating macrophages may be responsible for the mesangial phenotypic changes. The interaction between mesangial cells and infiltrating macrophages is now under investigation in view of glomerular expression of macrophage-colony stimulating factor.
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