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1997 Fiscal Year Final Research Report Summary

Molecular mechanisms for regulation of Mn-superoxide dismutase gene expression and physiological significance of the gene regulation.

Research Project

Project/Area Number 08671307
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionTokyo Women's Medical College

Principal Investigator

IOT Katsumi  Tokyo Women's Medical College Dept.of Pediatric Nephrology, School of Medicine Professor, 医学部, 教授 (90056771)

Co-Investigator(Kenkyū-buntansha) TUNODA Yuri  Tokyo Women's Medical College Dept.of Pediatric Nephrology, School of Medicine I, 医学部, 助手 (00256512)
HATTORI Motoshi  Tokyo Women's Medical College Dept.of Pediatric Nephrology, School of Medicine I, 医学部, 助手 (50192274)
YOSHIOKA Tosyimasa  Tokyo Women's Medical College Dept.of Pediatric Nephrology, School of Medicine A, 医学部, 助教授 (60146438)
Project Period (FY) 1996 – 1997
KeywordsPolymorphism / Henoch-Schonlein purpura nephritis / Proteinuria / lgA nephropathy / Clonic glmerulonephritis / Kidney disease / angiotensin-converting enzyme
Research Abstract

Objectives : Genetic influence of polymorphism of the 16th intron of the angiotensin-converting enzyme (ACE) gene on clinical manifestation of Henoch-Schonlein purpura nephritis (HSPN) and lgA nephropathy was studied. Study design : ACE gene polymorphism was determined in patients (4-15 yr at onset) with HSPN (n=40) and lgA nephropathy (n=79). Results : Initial clinical manifestations of both diseases were not different among homozygotes for insertion (II), heterozygotes (ID) and DD genotypes of ACE.In HSPN,the incidence of moderate to heavy proteinuria at 4 and 8 years after onset was some 4 times higher in DD than in II/ID genotypes. In contrast, no such trend was observed in lgA nephropathy. The number of patients in whom proteinuria resolved at 4 and 8 years after onset was significantly lower in DD compared to II and ID genotypes. Again, no difference was detected among 3 genotypes of patients with lgA nephropathy. Serum ACE activities in patients with DD genotype were significantly elevated. Conclusion : ACE DD genotype predicts persistent proteinuria in HSPN.The proteinuria may be related to a deviated angiotensin system which is genetically determined by the D/I polymorphism. In contrast, such genetic characteristics may not be an unique determinant of prolonged proteinuria in children with lgA nephropathy.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 伊藤 克己、服部 元史: "紫斑病性腎炎" 治療(増刊号 標準ガイド96). 78. 772-772 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 伊藤 克己、白髪 宏司: "新しい診断指針、治療の進歩Henoch-Schonlein purpura腎炎" 内科. 77(3). 458-463 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 吉岡 俊正: "Glomerular hyperfiltration" 内科. 77(6). 1146-1146 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 服部 元史、伊藤 克己: "マクロファージの糸球体内浸潤と糸球体硬化" 腎と透析. 42(2). 173-177 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 白髪 宏司、伊藤 克己: "感染由来のHUSに対する血液浄化療法" Clinical Engineerring. 8(8). 708-713 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 伊藤 克己: "小児溶血性尿毒症症候群(HUS)の病態と治療" 大阪透析研究会会誌. 15(1). 7-12 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshioka T,Iwamoto N,Ito K: "An application of electron paramagnetic resonance to evaluate nitric oxide and its quentures" J Am Soc Nephrol. 7(6). 961-965 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hattori M,Kawaguchi H,Matunaga A,Watanabe S,Kono M,Ito K: "Effects of LDL apheresis on renal injury seen in patients steroid-resistant focal esgmental glonerulosclerosis." Jpn I Apheresis (abstr.). 15. 52 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tunoda Y,Ito K,Iwanoto N,Shiraga H,Hattori M,Yoshioka T: "The interactions between glucocorticoid recepters and chaperone molecules may determine seroid sensitivity in patients with idiopathic nephrotic syndrome." J Am Soc Nephrol.7(9). 1345 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Xu Y,Yoshida H,Tunode Y,Shiraga H,Hattori M,Iwanmoto N,Kawaguchi H,Ito K,Yoshioka T: "The delition polymorphism of angiotensin converting enzyme predicts proteinuria in Henoch-Scholein purpure nephritis.." J Am Soc Nephrol.7(9). 1346 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwamoto N.Ito K,Kakuchi J,Yoshioka T: "Quenching of Nitric Oxide by an Oral Carbonaceous Absorbent." Jpn.J.Pharmacol. 74. 213-216 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshioka Y,Iwamoto N,Tunida Y,Higuchi C,Kwaguchi H,Ito K: "Down regulation of manganese-superoxide dismutase gene expression in idiopathic nephrotic syndrome." J.Pediatr.130(5). 800-807 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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