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1997 Fiscal Year Final Research Report Summary

Functional deficiency of pulmonary surfactant in the newborn infant

Research Project

Project/Area Number 08671320
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionSaitama Medical School

Principal Investigator

OGAWA Yunouske  Saitama Medical School, Pediatrics, Professor, 医学部, 教授 (90080126)

Co-Investigator(Kenkyū-buntansha) KANEKO Koji  Saitama Medical School, Pediatrics, Instructor, 医学部, 助手 (30224596)
ITAKURA Yukino  Saitama Medical School, Pediatrics, Instructor, 医学部, 助手 (70223071)
ARAKAWA Hiroshi  Saitama Medical School, Pediatrics, Instructor, 医学部, 助手 (90271238)
NAKAMURA Toshihiko  Saitama Medical School, Pediatrics, Instructor, 医学部, 助手 (30255137)
SHIMIZU Hiroshi  Saitama Medical School, Pediatrics, Lecturer, 医学部, 講師 (90260843)
Project Period (FY) 1996 – 1997
Keywordspulmonary surfactant / functional deficiency / acute respiratory distress syndrome / bronchoalveolar lavage fluid / superoxide anion / superoxide dismutase / newborn infant
Research Abstract

In order to elucidate the pathophysiology of functional deficiency of pulmonary surfactant in the newborn infants, an animal model of acute respiratory distress syndrome was produced in the newborn piglet by the administration of endotoxin (lipopolysaccharides : LPS) via trachea. In this animal model, multiple organ failure was eliminated and solely the lung pathology similar to human ARDS due to septicemia could be achieved. The lung pathology was confirmed by the decreased surface activity, progressive hypoxemia and hypercarbia, decreased lung compliance, increased O_2 productivity, increased elastase activity, and increased lipid peroxides in bronchoalveolar lavage fluid (BAIF). Lung pathology was confirmed also by histological examination on autopsy.
Then, the effect of prophylactically and therapeutically administered recombinant human superoxide dismutase (rh-SOD) on acute lung injury was evaluated. The prophylactic intratracheal administration of rh- SOD for lung injury caused by endotoxin was effective, It was confirmed by the maintenance of normoxemia and normocapnia, and lung compliance, and decreased production of lipid peroxides. Histologic examination also showed that the degrees of lung injury were milder in SOD pretreated animals.
However, after the formation of lung injury, the intratracheal administration of rh-SOD was no more effective on the improvement.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 高崎二郎, 中村利彦, 清水浩, 小川雄之亮,: "慢性肺疾患IおよびII型の発症と日齢1から28までの気道吸引液中インターロイキン8および顆粒球エラスターゼ" 日本未熟児新生児学会雑誌. 9・1. 37-41 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中村利彦, 板倉敬乃, 金子広司, 他: "経気道的スーパーオキシドディスムターザ(SOD)投与に関する基礎的検討" 日本未熟児新生児学会雑誌. 9・1. 43-49 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中村利彦, 小川雄之亮: "豚新生仔の経気道的エンドトキシン投与による急性肺傷害モデルの作成" 日本未熟児新生児学会雑誌. 9・1. 95-103 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takasaki J, Ogawa Y.: "Interleukin B and granulocyte elastase in the tracheo bronchial aspirate of infants without respiratory distress syndrome or intrauterine infection and development of chronic lung disease" Acta Pediatr Jpn. 39・4. 437-441 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小川雄之亮: "新生児慢性肺疾患予防の戦略" 日本新生児学会雑誌. 33・4. 421-428 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogawa Y, Takasaki J, Itakura Y, Shimizu H.: "Epidemiology and classification of chronic lung disease" Pediatr Pulmonol. Suppl16. 25-26 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 板倉敬乃、清水浩、金子広司、荒川浩、網塚貴介、小川雄之亮: "Acute respiratory distress syndrome (ARDS)における気道および血清SP-Aの検討-肺炎球菌感染症による溶血性尿毒症症候群に合併したARDSの1女児例-" 日本界面医学会雑誌. 28・1-2. 4112-1148 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 荒川浩、清水浩、金子広司、小川雄之亮、: "サーファクタント蛋白質Aの肺胞腔から血中への移行-新生児窮迫症候群における検討-" 日本新生児学会雑誌. 28巻1,2. 109-110 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura T, Ogawa Y.: "The model of acute lung injury induced by intratracheal administration of endotoxin in neonatal piglets" J Jpn Soc Newborn Premature Med. 9(1). 95-103 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura T, Itakura Y, Kaneko K, Arakawa H, Ohama Y, Takasaki J, Takada E, Shimizu H, Ogawa Y.: "Effects of intratracheal administration of recombinant human superoxide dismutase in rats" J Jpn Soc Newborn Premature Med. 9(1). 43-48 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takasaki J, Ogawa Y.: "Interleukin 8 and granulocyte elastase in the tracheobronchial aspirate of infants without respiratory distress syndrome or intrauterine infection and development of chronic lung disease" Acta Pediatr Jpn.39(4). 437-441 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takasaki J, Nakamura T, Shimizu H, Ogawa Y.: "Interleukin 8 and granulocyte elastase in the tracheobronchial aspirate of infants with respiratory distress syndrome and the development of chronic lung disease" J Jpn Soc Newborn Premature Med. 9(1). 37-41 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogawa Y, Takasaki J, Itakura Y, Shimizu H.: "Epidemiology and classification of chronic lung disease" Pediatr Pulmonol. Suppl 16. 25-26 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Itakura Y, Shimizu H, Kaneko K, Arakawa H, Amizuka T, Ogawa Y.: "Serial SP-A levels in airway specimen and serum of a pediatric patient with acute respiratory distress syndrome after hemolytic uremic syndrome due to streptococcus pneumoniae infection" J Jpn Med Soc Biol Interface. 28(1,2). 40-45 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Arakawa H, Shimizu H, Kaneko K, Ogawa Y.: "Alveolar-to-vascular leakage of surfactant protein A in newborn infants with respiratory distress syndrome" J Jpn Med Soc Biol Interface. 28(1,2). 109-110 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogawa Y.: "The strategy for the prevention of chronic lung disease" Acta Neonatol Jpn. 33(4). 421-428 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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