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1997 Fiscal Year Final Research Report Summary

The optimal infusion rate of medium-chain triglyceride/long-chain triglyceride emulsion (MCT/LCT) during plasma insulin clamp

Research Project

Project/Area Number 08671355
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionMie University

Principal Investigator

MIKI Chikao  Mie University Eaculty of Medicine Assistant, 医学部, 助手 (50242962)

Co-Investigator(Kenkyū-buntansha) IRIYAMA Keiji  Mie University Eaculty of Medicine (Research Collaborator)
Project Period (FY) 1996 – 1997
Keywordslipid emulsion / medium-chain fatty acid / long-chain fatty acid / triglyceride hydrolysis / triglyceride clamp technique / insulin clamp
Research Abstract

As medium-chain triglyceride emulsions (MCT) are more rapidly hydrolyzed than long-chain triglyceride emulsions (LCT), MCT/LCT tends to be infused faster than LCT.The purpose of this research project was to determine the most appropriate infusion rate for MCT/LCT to stabilize plasma concentrations of triglyceride (TG), being equivalent to the optimal infusion rate of the emulsion. A TG clamp was set up by raising the mean (]SY.+-。[) s.d.concentrations of TG in plasma, being 1.08 (]SY.+-。[) 0.18 delta-mmol/l for LCT,and 1.65 (]SY.+-。[) 0.31 delta-mmol/l for MCT/LCT after a 50-min priming infusion of each emulsion. Thereafter, the infusion rate of lipid was controlled every 10 min to maintain a steady concentration of TG for a period of 150 min. A constant infusion of glucose at 0.32 g/kg/h was given for the test period. The weight-based rate of the infusion to maintain a steady state of plasma TG concentrations did not differ between MCT/LCT and LCT,being 0.125 (]SY.+-。[) 0.013 versus 0.117 (]SY.+-。[) 0.021 g/kg/h, while the molar-based infusion rate was 0.203 (]SY.+-。[) 0.021 mmol/kg/h for MCT/LCT and 0.132 (]SY.+-。[) 0.023 mmol/kg/h for LCT.These results suggest that although 54% more molar MCT/LCT can be hydrolyzed during a constant infusion, MCT/LCT should not be infused at a rate faster than 0.1 g/kg/h under a steady state.
Apolipoprotein C-II (apo C-II) is essential for TG hydrolysis. It was investigated in vitro if the amounts of apo C-II acquired by lipid particles are different between MCT and LCT.The results demonstrated that there was no differences in the amounts of in vitro transfer of apo C-II from high-density lipoprotein to lipid particles between MCT and LCT.However, it was suggrested that MCT-TGs require less amounts of apo C-II than LCT in the process of hydrolysis, since the mean amount of apo C-II acquired by one micro-mol of MCT-TG was less than that acquired by one micro-mol of LCT-TG.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Keiji Iriyama: "Elimination rate of fat emlsion particles from plasma in Japanese subjects as determined by a triglyceride clamp technique." Nutrition. 12. 79-82 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Keiji Iriyama: "Elimination of fat emulsion particles from plasma during glucose infusion." British Journal of Surgery. 83. 946-948 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Keiji Iriyama: "The metabolic distinctiveness of emulsified lipid particles in the bloodstream and its clinical implications." Surgery Today. 26. 673-678 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Keiji Iriyama: "Constant infusion rates of lipid emulsions to stabilize plasma triglyceride concentrations: Medium-chain triglyceride/long-chain triglyceride(MCT/LCT)versus LCT." Surgery Today. 28(3)(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 入山 圭二: "MCT含有脂肪乳剤の代謝特性と将来展望" 医学のあゆみ. 183. 743-746 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 入山 圭二: "中鎖・長鎖混合脂肪乳剤(MCT/LCT)の至適投与速度" 日本静脈・経腸栄養研究会誌. 12. 184-186 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iriyama K,Carpentier YA.: "Clinical significance of transfer of apolipoproteins between triacylglycerol-rich particles in lipid emulsion and plasma lipoproteins." Nutrition. 10. 252-254 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iriyama K,Tsuchibashi T,Miki C,Iunga K,Li H,Urata H,Saitoh R.: "Elimination rate of fat emulsion particles from plasma in Japanese subjects as determined by a triglyceride clamp technique." Nutrition. 12. 79-82 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iriyama K,Tsuchibashi T,Urata H,Miki C,Ilunga K,Li H,Carpentier YA.: "Elimination rate of fat emulsion particles from plasma during glucose infusion." Br J Surg. 83. 946-948 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iriyama K.: "The metabolic distinctiveness of emulsified lipid particles in the bloodstream." Surg Today. 26. 673-678 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iriyama K,Miki C,Inoue T,Kawarabayashi N,Urata H,Shigemori C.: "Constant infusion rates of lipid emulsions to stabilize plasma concentrations ; Medium-chain triglyceride/long-chain triglyceride (MCT/LCT) versus LCT." Surg Today. 28 : no.3(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iriyama K.: "Metabolic distinctiveness of MCT-containing lipid emulsions and its clinical implications. (in Japanese)" IGAKUNOAYUMI. 183. 743-746 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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