1997 Fiscal Year Final Research Report Summary

Cell dynamics from the viewpoint of cell proliferation and cell death in several hereditary intestinal polyposis syndrome.

Research Project

Project/Area Number	08671417
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Digestive surgery
Research Institution	Sasaki Institute (1997) Tokyo Medical and Dental University (1996)
Principal Investigator	IWAMA Takeo Sasaki Institute, Fellow, 外科, 研究員 (70114741)
Project Period (FY)	1996 – 1997
Keywords	Familial adenomatous polyposis / Juvenile polyposis / Peutz-Jeghers syndrome / Cell proliferation / Apoptosis
Research Abstract	The patients included 15 adenomas in FAP(familial adenomatous polyposis), 3 Juvenile polyposis, 5 Peutz-Jeghers syndrome, 14 sporadic adenomas, 46 sporadic colorectal carcinomas and 20 normal colorectal epithelium. The specimen were processed for TUNEL(terminal uridine deoxyuncleotide nick end labeling)and PCNA(proliferating cell nuclear anatigen)staining. Adenomas showed high PCNA and TUNEL indices compared to the normal epithelium. There were no differences in TUNEL and PCNA indices between adenomas of FAP and sporadic adenomas. Juvenile polyposis showed no TUNEL and PCNA positive cells. Peutz-Jeghers syndrome showed high PCNA indices and normal TUNEL indices. Carcinoma showed higher PCNA and TUNEL indidces was useful in refleclting difference of cell proliferation between differnt hereditary conditions.

(4 results)