1997 Fiscal Year Final Research Report Summary

Study of the anglogenesls as a tumor microenvironment fot the establlshment for new therapeutic strategy.

Research Project

Project/Area Number	08671426
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Digestive surgery
Research Institution	Kanazawa University
Principal Investigator	TAKAHASHI Yutaka Kanazawa University, Cancer Research, Institute Surgery, Associate Professor, がん研究所, 助教授 (10179541)
Project Period (FY)	1996 – 1997
Keywords	gastric cancer / angiogenesis / VEGF / PD-ECGF
Research Abstract	Angiogenesis is essential for tumor growth and metastasis and depends on the production of angiogenic factors by host and/or tumor cells. We studied the role of angiogenesis and angiogenic factors in human gastric cancer. Vascular endothelial growth factor (VEGF), one of angiogenic factors, was produced by tumor cells and was a responsible factor for the induction of angiogenesis in intestinal-type gastric cancer. And platelet derived endothelial cell growth faftor (PD-ECGF), another angiogenic factor, was kexpressed in infiltrating cells and correlated with VEGF expression in tumor cells. Angiogenesis was greater in tumors with both high VEGF and PD-ECGF expression than those with high expression of either factor alone. These results suggest that multiple angiogenic factors expressed by both tumor cells and infiltrating cells may play a role in eegulation of angiogenesis in intestinal-type gastric cancer.