1997 Fiscal Year Final Research Report Summary
INFLUENCE OF THE ORDER OF HEPATIC ARTERIAL AND PORTAL VENOUS REPERFUSION ON THE GRAFTIN RATHEPATIC TRANSPLANTATION
| Project/Area Number |
08671430
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | SHINSHU UNIVERSITY,SCHOOL OF MEDICINE |
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Principal Investigator |
IKEGAMI Toshihiko SHINSHU UNIV., SCHOOL OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 助手 (60232170)
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| Project Period (FY) |
1996 – 1997
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| Keywords | LIVER TRANSPLANTATION / HEPATIC7 ARTERIAL RECONSTRUCTION / LIVING-RELATED LIVER TRANSPLANTATION / HEPATIC ARTERIAL REPERFUSION / PORTAL VENOUS REPERFUSION |
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| Research Abstract |
In living-related liver transplantation, the hepatic arterial reconstruction is one of the most critical point, and the way to reconstruct hepatic artery is under investigation. Here, we can get the results below ; (1) introduction of the microvascular surgery to hepatic arterial reconstruction is effective, (2) when several hepatic arteries may supply the potential graft, it is not always necessary to reconstruct all of them, if pulsatile back-bleeding from the stumps of the non-anastomosed graft arteries, and pulsatile intrahepatic arterial flow in every segment of the grafts upon color Doppler ultrasound examination after reconstruction of the largest artery, (3) no hepatic arterial thromboses were experienced in our 83 series of living-related liver transplantation.
In rat liver transplantation, the importance of hepatic arterial reconstruction was determined from the body weight gain and biochemical parameters after liver transplantation by the comparison of the hepatic arterial reconstructed group and non-reconstructed group.
When hepatic arterial reperfusion was performed followed by portal venous reperfusion after portal venous and hepatic arterial reconstruction, or when portal venous reperfusion was performed followed by hepatic arterial reperfusion after portal venous and hepatic arterial reconstruction, the most of the rats in both groups died because of the longer period of anhepatic phase. The Influence of the order of hepatic arterial and portal venous reperfusion on the graft should be determined using the model which tolerates the longer period of anhepatic phase.
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