1997 Fiscal Year Final Research Report Summary
Prognostic significance of E-cadherin expression in human colorectal cancer tissue
| Project/Area Number |
08671434
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
SUZUKI Hiroshi Mie University Faculty of Medicine, Professor, 医学部, 教授 (20004632)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Koichi Mie University Faculty of Medicin, Associate Professor, 医学部, 助教授 (80024694)
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| Project Period (FY) |
1996 – 1997
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| Keywords | colorectal cancer / E-cadherin / cell adhesion molecule / immunohistochemistry |
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| Research Abstract |
The expression f E-cadherin was determined by immunohistochemical staining in tumor and in adjacent normal mucosae taken from 100 resected specimens of colorecatal carcinomas. The expression of E-cadherin was preserved in all normal mucosae, but in the tumor tissue specimens it was presered in 43, heterogenous in 32, and lost in 25 samples. The lost or heterogenous expression of E-cadherin correlated closely to the following : an advanced clinical stage of clorectal cancer, advanced tumor penetration, undifferentiated tumor histoloy, widespread lymph node inolvement, liver metastasis, and permeation into the lymphatic and venous channels. The lost or heterogenous expression of E-cadherin in tumor tissue was also sinificantly associated with an increased incidence of tumor recurrence after apparently curative resection, a reduced overall survival rate, and a reduced disease-free patient survival rate. A multivariate analysis disclosed that the expression of E-cadherin in tumor tissue was a significant prognostic variable indpendent of other clinicopathological features.
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