1997 Fiscal Year Final Research Report Summary

MECHANISTIC ANALYSIS AND ENHANCEMENT OF CELL DEATH OF HUMAN PANCREATIC CANCER CELL LINE EXPOSED BY HIGH DOSE X-RAY IRRADIATION - FOR THE IMPROVEMENT OF ADJUVANT CHEMOTHERPY OF PANCREATIC CANCER

Research Project

Project/Area Number	08671457
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Digestive surgery
Research Institution	KYUSHU UNIVERSITY
Principal Investigator	MIZUMOTO Kazuhiro KUSHU UNIVERSITY,ASSISTANT PROFESSOR, 医学部, 助手 (90253418)
Co-Investigator(Kenkyū-buntansha)	TANAKA Masao KYUSHU UNIVERSITY,PROFESSOR, 医学部, 教授 (30163570) SHIMURA Hideo FUKUOKA UNIVERSITY,AASOCIATE PROFESSOR, 医学部, 助教授 (80178996)
Project Period (FY)	1996 – 1997
Keywords	PANCREATIC CANCER / RADIATION / APOTOSIS / RADIATION ENHANCEMENT
Research Abstract	Effect of etoposide on the cell deaths of a human pancreatic cancer cell line by exposure to high dose X-ray irradiation was examined. Both high dose X-ray irradiation and etoposide killed the pancreatic cancer cells by apoptosis. With 30 gray irradiation, simultaneous treatment of etoposide did not alter the percentage of cell deaths ; however, 24-hr prior treatment of etoposide killed a significantly larger percentage of the cells, accompanying the accumulation to the S phase of the cell cycle. The results indicates that apoptosis of human pancreatic cancer cell line induced by high dose X-ray irradiation can be enhanced by the prior treatment of etoposide.