1997 Fiscal Year Final Research Report Summary
MECHANISTIC ANALYSIS AND ENHANCEMENT OF CELL DEATH OF HUMAN PANCREATIC CANCER CELL LINE EXPOSED BY HIGH DOSE X-RAY IRRADIATION - FOR THE IMPROVEMENT OF ADJUVANT CHEMOTHERPY OF PANCREATIC CANCER
| Project/Area Number |
08671457
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
MIZUMOTO Kazuhiro KUSHU UNIVERSITY,ASSISTANT PROFESSOR, 医学部, 助手 (90253418)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Masao KYUSHU UNIVERSITY,PROFESSOR, 医学部, 教授 (30163570)
SHIMURA Hideo FUKUOKA UNIVERSITY,AASOCIATE PROFESSOR, 医学部, 助教授 (80178996)
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| Project Period (FY) |
1996 – 1997
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| Keywords | PANCREATIC CANCER / RADIATION / APOTOSIS / RADIATION ENHANCEMENT |
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| Research Abstract |
Effect of etoposide on the cell deaths of a human pancreatic cancer cell line by exposure to high dose X-ray irradiation was examined. Both high dose X-ray irradiation and etoposide killed the pancreatic cancer cells by apoptosis. With 30 gray irradiation, simultaneous treatment of etoposide did not alter the percentage of cell deaths ; however, 24-hr prior treatment of etoposide killed a significantly larger percentage of the cells, accompanying the accumulation to the S phase of the cell cycle. The results indicates that apoptosis of human pancreatic cancer cell line induced by high dose X-ray irradiation can be enhanced by the prior treatment of etoposide.
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