1997 Fiscal Year Final Research Report Summary
Radioisotope rabeled monoclonal antibody guided surgery for early gastric canccer.
| Project/Area Number |
08671470
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KITAMURA Kazuya Kyoto Prefectural University of Medicine. Surgery I,Assistant., 医学部, 助手 (10224966)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Early gastric cancer / Monoclonal antibody / Radioisotope / Surgery |
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| Research Abstract |
This study was designed to determine the clinical effectiveness of 131-I rabeled human mouse chimeric monoclonal antibody A7 for radioimmunogided surgery. The radiolabed antibody was administered iv to 11 patients with gastric or colorectal cancer 3 days before surgery. Gamma detection probe was used for identifying target tumor. In eigth patients, primary tumor was identified intraoperatively and in two patients, lymph node metastasis was found. This result indicates that although monoclonal antibody is a promising tool for enhancing the effectiveness of monoclonal antibody A7 in radioimmunoguided surgery.
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[Publications] Kazuya Kitamura, Toshiharu Yamaguchi, Satoki Nishida, Kazuhito Yamamoto, Kazuma Okamoto, Morio Shirasu, Chouhei Sakakura, Eigo Otsuji, Hiroki Taniguchi, Akeo Hagiwara, Kiyoshi Sawai, Toshio Takahashi: "Clinicopathologic features of primary early gastric lymphoma." J Kyoto Pref Univ Med. 106. 559-562 (1997)
Description
「研究成果報告書概要(欧文)」より
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